Gemcitabine

Molecular formula CgHnF2N304 Molecular weight 263.20 CAS Registry No 95058-81-4 Merck Index 13,4397 [Pg.296]

Sample preparation Mix 6 mL blood with 100 iJiL 10 mg/mL tetrahydrouridine, a cytidine deaminase inhibitor, centrifuge at 1200 g for 15 min to obtain plasma. Vortex 100 (aL plasma and 10 (jiL 40% trichloroacetic acid for 1 min, centrifuge at 10000 g at 4 for 5 min, inject a 25 jiL aUquot of the supernatant. [Pg.296]

Mobile phase MeOHibuffer 17 83 (The buffer was 20 mM pH 3.1 ammonium dihydrogen phosphate buffer containing 10 mM sodium 1-heptanesulfonate.) [Pg.296]

Noordhuis, P. Peters, G.J. An expedient assay for determination of gemcitabine and its metabolite in human plasma using isocratic ion-pair reversed-phase high-performance liquid chromatography, Ther.Drug Monit., 2003,25, 552-557. [Pg.296]

Mobile phase 13.8 g/L sodium dihydrogen phosphate containing 2.5 mL/L phosphoric acid [Pg.296]

Gemcitabine (Fig. 7) is a cytosine derivative that is very similar to ara C. It undergoes metabolic activation to difluorodeoxycytidine triphosphate, which interferes... [Pg.151]

Anti metabolites. Figure 7 Chemical structure of gemcitabine (gemzar). [Pg.151]

CnH3 F204Si2) see Gemcitabine iV,0-bis(4-chlorobenzoyl)tyr amine (C22H17CI2NO5 4/859-56-7) see Bezafibrate bis(2-chloroethyl)amine (C4H9CI2N 334-22-5) see Cyclophosphamide Estramustine phosphate... [Pg.2309]

Gemcitabine Myelosuppression (especially thrombocytopenia) Flulike syndrome (fever, chills, myalgias, arthralgias), nausea... [Pg.1313]

Cisplatin-gemcitabine renal, neuropathy, weakness, hypersensitivity, anemia Febrile neutropenia, infection, thrombocytopenia, nausea, vomiting, High (day 1) Mild (days 8 and 1 5)... [Pg.1330]

Gemcitabine-docetaxel Nausea and vomiting, diarrhea, thrombocytopenia, asthenia, Moderate... [Pg.1330]

More recently, a German study compared a dose-escalated regimen of BEACOPP (with filgrastim support) with standard-dose bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone, gemcitabine (BEACOPP) and COPP alternating with ABVD (C—cyclophosphamide instead of mechlorethamine for MOPP).18 The escalated BEACOPP was... [Pg.1378]

Gemcitabine 800 mg/m2 IV infused over 30 minutes once a week on days 1,8, 1 5, followed by 1 week of rest 13.9%-27% Myelosuppression (DLT), flulike symptoms, headache, somnolence, nausea/vomiting, stomatitis, diarrhea, constipation, rash ... [Pg.1393]

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