Bioreactors design/operational strategy

The present survey addresses studies on azo-dye conversion by means of bacteria, with a close focus on bioreactor design and operational strategies. Other chapters of the Handbook and recently published reviews [1, 2] address instead the detailed biochemical pathways underlying azo-dye conversion and the fate of the conversion products. 

Cultivation of NSO cells in an AcuSyst Jr hollow-fiber bioreactor comparison of two different operation strategies, designated basic and optimized strategy (Rodriguez et al., 2005). 

The microscale processes demonstrated in Fig. 3 are intrinsic to SSF due to the particulate nature of the substrate. They occur in all bioreactors and relatively little can be done to influence them in the way the bioreactor is designed and operated since they occur at the surface and inside the individual substrate particles. The most that can be achieved through bioreactor design and operational strategies is to promote exchange between the particle and air phases and to ensure that the transport processes within the air phase are not limiting. 

Yabannavar et al. [81] used Eqs. (19) and (20) for scale-up purposes. Based on successful operation conditions determined for an existing 12-L bioreactor, they calculated the spin-filter dimensions and operation conditions for an existing 175-L bioreactor. Experiments with the spin-filter designed for the large-scale bioreactor resulted in an absence of filter clogging with cell retention efficiency similar to the 12-L bioreactor. This was considered as an evidence that the suggested scale-up strategy is adequate. 

Beaubien, A., Baty, M., Jeannot, F., Francoeur, E., Manem, J. (19%). Design and operation of anaerobic membrane bioreactors development of a filtration testing strategy. Journal of Membrane Science, 109, 173—184. 

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