Animal cell culture systems bioreactor design

Three major intellectual frontiers for chemical engineers in bioprocessing are the design of bioreactors for the culture of plant and animal cells, the development of control systems along with the needed biosensors and analytical instraments, and the development of processes for separating and purifying products. A critical component in each of these three research areas is the need to relate the micro-scale to the mesoscale. 

Wamock and Al-Rubeai (29) have reviewed bioreactor systems for the production of biopharmaceuticals via culture of animal cells. They describe the advantages and disadvantages of several types of bioreactors and the huge expansion of commercial-scale culture facilities in the early 2000s. Early bioreactor designs for culture of animal cells focused on anchorage-dependent cell lines (see below), but in many cases these bioreactors may also be adapted for the culture of suspended cells. 

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