Bioreactor design drum bioreactors

Until now, bioreactors of various types have been developed. These include loop-fluidized bed [14], spin filter, continuously stirred turbine, hollow fiber, stirred tank, airlift, rotating drum, and photo bioreactors [1]. Bioreactor modifications include the substitution of a marine impeller in place of a flat-bladed turbine, and the use of a single, large, flat paddle or blade, and a newly designed membrane stirrer for bubble-free aeration [13, 15-18]. Kim et al. [19] developed a hybrid reactor with a cell-lift impeller and a sintered stainless steel sparger for Thalictrum rugosum cell cultures, and cell densities of up to 31 g L1 were obtained by perfusion without any problems with mixing or loss of cell viability the specific berberine productivity was comparable to that in shake flasks. Su and Humphrey [20] conducted a perfusion cultivation in a stirred tank bio-... 

Four basic types of SSF bioreactors have been developed (Figs. 3 and 4). These are (1) drum bioreactor [16], (2) packed bed bioreactor [17,18], (3) tray bioreactor [4, 16], (Ahmed et al. 1987 Hesseltme 1987 Pandey 1991 cited in [19]), and (4) column bioreactor (Raimbault and Germon 1976 cited in [20]). The structure and nature of the solid matrix used, type of microorganism involved, environmental conditions needed for the process, the type of use (research or industrial applications), and type of product should all be considered for the selection of appropriate design of bioreactor [19]. 

A variation of the stirred bed design involves a horizontal stirred drum, filled to two-thirds depth with substrate, with introduction of air through a perforated central shaft embedded in the substrate bed and upon which mixer blades are mounted (Fig. 10). This bioreactor has been successfully used for... 

A similar approach applied to rotating drum bioreactors gives a dimensionless design factor [167] ... 

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