Principles and Special Considerations for Bioreactor Design

There are three primary modes of operation to be considered in the design of a bioreactor. These modes include operation as 

A well-mixed batch reactor whose contents are regarded as pseudo-homogeneous in temperature and composition throughout the entire volume occupied by the suspended cells. Aerobic bioreactions are often carried out in a semibatch mode of operation in which oxygen or air is bubbled continuously through the 

The functional equivalent of a PFBR (plug flow bioreactor) when selectivity, inhibition by product species, or other considerations dictate the desirability of striving to avoid mixing of volume elements that are characterized by different degrees of conversion. 

The primary modes of operation mentioned above for bioreactors are similar to those for the conventional 

The material and energy balance equations used in the design and analysis of a well-agitated batch reactor were presented earlier as equations (8.1.5) and (10.2.6), respectively  

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