Bioreactor Performance Process Design Methods

The problems posed by the interaction of the reactor type and the physiology of the organism have only slowly been recognized (Finn and Fiechter, 1979 Melling, 1977 A. Moser, 1983a and b), cf. Sect. 3.3.11 and Leegwater et al. (1982). 

The present chapter will deal with general methods that are suitable for making predictions in developing a process on the basis of kinetic data usually obtained from measurements made in a discontinuously operated stirred vessel. The design equation may be written in a qualitative way as 

Equation 6.1 is a generalized form of the conservation of mass equation (cf. Equ. 2.3). 

The influence of the OTR on kinetics (and therefore on productivity) was indicated in Equs. 5.169 and 5.170. Therefore, we will discuss here primarily those process engineering factors involved in various different types of reactors and operations. Last but not least, some unconventional reactors such as membrane (dialysis) reactors and synchronous culture techniques will be discussed. 

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