Biomedical Applications of Nanofibers

Science and Technology of Polymer Nanofihers. By Anthony L. Andrady Copyright 2008 John Wiley Sons, Inc. 

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Some of the biomedical application of nanofibers is to cure for wound and burnings in human skin. It can be designed for especially hemostatic tools. Electrospun biodegradable polymers can be spun onto the wound skin. They form a thin web onto the skin. This web protects skin from microbes. Moreover, it helps to heal the wound quickly. Finally, it minimizes the possibility of scars. Electrospun nanofiber equipment used in wound healing is shown in Fig. 2.2. 

Biomedical Applications of Polymer/Silver Composite Nanofibers... 

The present volume entitled, Biomedical Applications of Polymeric Nanofibers attempts to provide a broad overview on the preparation techniques, structures and biomedical applications of different biopolymeric nanofibers. The book consists of 9 chapters ... 

Nanofibrous mats can also act as ion exchangers [45,46] which have faster kinetics compared to the classical, granular systems. SEM image of pollens of Aesculus hippocas-tanum filtered by electrospun media can be seen in Figure 10.3. It is worth mentioning that nanofibers have approximately two orders of magnitude lower p>ore size than the size of the pollens, therefore even smaller items can be filtered such as bacteria, which points to the biomedical applications of electrospun nanofibers. 

K. Azuma, S. Ifuku, T. Osaki, Y. Okamoto, and S. Minami, Preparation and biomedical applications of chitin and chitosan nanofibers, /. Biomed. Nanotechnol, 10, 2891-2920, 2014. 

Advances in biomedical applications of nanomaterials require a multidisciplinary research orientation with a focus on both the engineering aspects of nanofiber mats as well as their biological interactions at the implant site. W.-J. Li et al. (2005a) suggest two promising directions for future research bioactivation and incorporation of controlled release functionality into polymers. 

Nanosized objects perform various functions in the biomedical field. In the human body, nanosized particulate substances behave very differently from larger particles. In 1986, Maeda et al. found that the stained albumin, having a size of several nanometers, naturally accumulates in the region of cancerous tissues, which is now well known as the enhanced permeability and retention (EPR) effect. Many studies in the field of nanoparticles are based on this finding. Another application of nanoparticles is the delivery system using various polyplexes that are composed of carrier molecules and plasmid DNA or nucleic acid drugs such as antisenses and siRNA. In addition, nanofibers are mainly used for biodegradable scaffolds in tissue... 

Stupp, S.I., Hartgerink, J.D., and Beniash, E. Self-Assembly of Peptide-Amphiphile Nanofibers Under Physiological Conditions for Biomedical Applications, 2003-US4779 2003070749 (2003b). 

Kim K et al (2003) Control of degradation rate and hydrophilicity in electrospun nonwoven poly (D, L-lactide) nanofiber scaffolds for biomedical applications. Biomaterials 24(27) 4977 985... 

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