Electrospun biodegradability

Li WJ et al (2007) Engineering controllable anisotropy in electrospun biodegradable nanofibrous scaffolds for musculoskeletal tissue engineering. J Biomech 40(8) 1686-1693... 

Kim, T.G. Lee, D.S. Park, T.G. Controlled protein release from electrospun biodegradable fiber mesh composed of poly(epsilon-caprolactone) and poly (ethylene oxide). Int. J. Pharm. 2007, 338 (1-2), 276-283. 

Ndreu A, Nikkola L, Ylikauppila H, Ashammakhi N, Hasirci V (2008) Electrospun biodegradable nanofibrous mats for tissue engineering. Nanomedicine 3 45-60 Nelson T, Kaufman E, Kline E, Sokoloff L (1981) The extraneural distribution of gammahy-droxybutyrate. J Neurochem 37 1345-1388... 

L. li, C.C. Chu, Nitroxyl radical incaporated electrospun biodegradable polyfester amide) nanofibo- membranes, J. Biomater. Sci. Polym. Ed. 20 (2009) 341-361. 

Some of the biomedical application of nanofibers is to cure for wound and burnings in human skin. It can be designed for especially hemostatic tools. Electrospun biodegradable polymers can be spun onto the wound skin. They form a thin web onto the skin. This web protects skin from microbes. Moreover, it helps to heal the wound quickly. Finally, it minimizes the possibility of scars. Electrospun nanofiber equipment used in wound healing is shown in Fig. 2.2. 

Kim, T.G. and Park, T.G. 2006. Surface functionalized electrospun biodegradable nanofibers for immobilization of bioactive molecules. BiotedmoL w ll 1108-1113. 

N. Goonoo, A. Bhaw-Luximon, D. Jhurry, Dmg loading and release from electrospun biodegradable nanofibers, J. Biomed. Nanotechnol. 10 (9) (2014) 2173—2199. 

Hashizume R, Fujimoto KL, Hong Y, Amoroso NJ, Tobita K, Miki T, et al. Morphological and mechanical characteristics of the reconstructed rat abdominal wall following use of a wet electrospun biodegradable polyurethane elastomer scaffold. Biomaterials April 2010 31(12) 3253-65. 

Punnakitikashem P, Truong D, Menon JU, Nguyen KT, Hong Y. Electrospun biodegradable elastic polyurethane scaffolds with dipyridamole release for small diameter vascular grafts. Acta Biomater 2014 10 4618-28. 

PLGA)), into which a drug (here dexamethasone, an anti-inflammatory drug) has been incorporated, followed by electrochemical deposition of a conducting polymer (here poly(3,4-ethylenedioxythiophene) PEDOT) around the drug-loaded, electrospun biodegradable polymers. Dexamethasone can be released from the PEDOT nanotubes in a desired fashion by subsequent electrical stimulation of the PEDOT nanotubes this process presumably proceeds by a local dilation or contraction of the tube that promotes mass transport. 

O. H. Kwon (2005). A composite of hydroxyapatite with electrospun biodegradable nanofibers as a tissue engineering material. Journal of Bioscience and Bioengineering 100(1) 43—49. 

Li, W. J., Mauck, R. L., Cooper, J. A., Yuan, X., and Tuan, R. S. 2007. Engineering controllable anisotropy in electrospun biodegradable nanofibrous scaffolds for musculoskeletal tissue engineering. /. Biomech. 40 1686-1693. 

---