Biomaterials polysaccharides

T. Kean, and M. Thanou, Chitin and chitosan Sources, production and medical applications, in Renewable Resources for Functional Polymers and Biomaterials Polysaccharides, Proteins and Polyesters. 2011, The Royal Society of Chemistry. Chap. 10,292-318. 

Within the scope of this review, the contributions of the last decade concerning cell-wall polysaccharides isolated from woody and other plant tissues will be reviewed according to the above-proposed classification of hemicelluloses including larch arabinogalactans. The present review article updates and extends previous reviews [3-5] and will focus in particular on new investigated plant sources, isolation methods, structural features, physicochemical and various functional properties of hemicelluloses. Attention will also be paid to the modification of isolated hemicelluloses or hemicellulosic materials and the appHcation possibiUties of hemicelluloses and their derivatives, including their use for the production of composite materials and other biomaterials. 

For thousands of years, nature has provided humankind with a large variety of materials for the most diversified applications for its survival, such as food, energy, medicinal products, protection and defense tools, and others. The pharmaceutical industry has benefitted from such diversity of biomaterials and has exploited the use of natural products as sources of both drugs and excipients. One example of a promising biomaterial for pharmaceutical use is xylan, a hemicellulose largely found in nature, being considered the second most abundant polysaccharide after cellulose. 

Applications of sol-gel-processed interphase catalysts. Chemical Reviews, 102, 3543-3578. Pierre, A.C. (2004) The sol-gel encapsulation of enzymes. Biocatalysis and Biotransformation, 22, 145-170. Shchipunov, Yu.A. (2003) Sol-gel derived biomaterials of silica and carrageenans. Journal of Colloid and Interface Science, 268, 68-76. Shchipunov Yu.A. and Karpenko T.Yu. (2004) Hybrid polysaccharide-silica nanocomposites prepared by the sol-gel technique. Langmuir, 20, 3882-3887. 

Abstract Carbohydrates have been investigated and developed as delivery vehicles for shuttling nucleic acids into cells. In this review, we present the state of the art in carbohydrate-based polymeric vehicles for nucleic acid delivery, with the focus on the recent successes in preclinical models, both in vitro and in vivo. Polymeric scaffolds based on the natural polysaccharides chitosan, hyaluronan, pullulan, dextran, and schizophyllan each have unique properties and potential for modification, and these results are discussed with the focus on facile synthetic routes and favorable performance in biological systems. Many of these carbohydrates have been used to develop alternative types of biomaterials for nucleic acid delivery to typical polyplexes, and these novel materials are discussed. Also presented are polymeric vehicles that incorporate copolymerized carbohydrates into polymer backbones based on polyethylenimine and polylysine and their effect on transfection and biocompatibility. Unique scaffolds, such as clusters and polymers based on cyclodextrin (CD), are also discussed, with the focus on recent successes in vivo and in the clinic. These results are presented with the emphasis on the role of carbohydrate and charge on transfection. Use of carbohydrates as molecular recognition ligands for cell-type specific dehvery is also briefly... 

Eliyahu H, Siani S, Azzam T et al (2006) Relationships between chemical composition, physical properties and transfection efficiency of polysaccharide-spermine conjugates. Biomaterials 27 1646-1655... 

Mizu M, Koumoto K, Anada T et al (2004) Antisense oligonucleotides bound in the polysaccharide complex and the enhanced antisense effect due to the low hydrolysis. Biomaterials 25 3117-3123... 

Chitin is a polysaccharide constituted of N -acctylglucosamine, which forms a hard, semitransparent biomaterial found throughout the natural world. Chitin is the main component of the exoskeletons of crabs, lobsters and shrimps. Chitin is also found also in insects (e.g. ants, beetles and butterflies), and cephalopods (e.g. squids and octopuses) and even in fungi. Nevertheless, the industrial source of chitin is mainly crustaceans. 

Despite of hybridization with biological ligands, the general strategy for optimizing protein adsorption on biomaterial surfaces relies on chemical or physicochemical modulation of surface hydrophilicity [38,39]. The common approach is surface immobilization of hydrophilic polymers like polyethylene glycol [PEG] or polysaccharides. Four categories of surface-modification pathways have been developed ... 

Scaffolds can be made from natural or synthetic materials. Such materials fall under the category of biomaterials. A biomaterial can be considered a single element or compound, which is a composite or mixture of elements, and is synthesized or derived to be used in the body to preserve, restore, or augment the structure or function of the body. Examples of natural materials for scaffold construction are extracellular matrix, collagen, fibrin, and polysaccharides (e.g., chitosan or glycosaminoglycans). Natural materials, unless they are obtained from the patient who receives the neo-organ implant, will cause an immunogenic response. This is not always the case with synthetic materials. 

Lemarchand, C., Gref, R., Passirani, C., Garcion, E., Petri, B., Muller, R., Costantini, D., and Couvreur, P. (2006), Influence of polysaccharide coating on the interactions of nanoparticles with biological systems, Biomaterials, 27(1), 108-118. 

Labarre, D., Vauthier, C., Chauvierre, C., Petri, B., Muller, R., and Chehimi, M. M. (2005), Interactions of blood proteins with poly(isobutylcyanoacrylate) nanoparticles decorated with a polysaccharidic brush, Biomaterials, 26(24), 5075-5084. 

Surface-bound, neutral, hydrophilic polymers such as polyethers and polysaccharides dramatically reduce protein adsorption [26-28], The passivity of these surfaces has been attributed to steric repulsion, bound water, high polymer mobility, and excluded volume effects, all of which render adsorption unfavorable. Consequently, these polymer modified surfaces have proven useful as biomaterials. Specific applications include artificial implants, intraocular and contact lenses, and catheters. Additionally, the inherent nondenaturing properties of these compounds has led to their use as effective tethers for affinity ligands, surface-bound biochemical assays, and biosensors. 

Suh, J.K.F. Matthew, H.W.T. Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering A review. Biomaterials 2000, 21, 2589-2598. 

Most of the procedures using multivariate data processing were used for qualitative purposes such as classification and identification of microorganisms, differentiation of capsular polysaccharides of different bacteria, or fossil biomaterials, etc. Quantitation was also possible in identifying adulteration of several foods [86]. 

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