Biocompatible-bioactive compounds

Based on the fact that fine-tuning of the physical and chemical properties of silicones is possible and that silicones are considered to be physiologically inert, the development of biocompatible silicone-based delivery systems for bioactive compounds seems a challenging... 

PEG is one of the most widely used polymers in the pharmaceutical field because it shows favorable features such as water solubility and biocompatibility, so that it has been used to confer solubility in the physiological environment and prevent the interaction with plasma proteins and cells, and is therefore used as shielding agent for in vivo delivery of several bioactive compounds [26,27]. 

Due to their highly biocompatible nature, dendritic PGs have a broad range of potential applications in medicine and pharmacology. The versatility of the polyglycerol scaffolds for application in the biomedical field has recently been reviewed [131], and a number of examples were described, therein, e.g., smart and stimuli-responsive delivery and release of bioactive molecules, enhanced solubilization of hydrophobic compounds, surface-modification and regenerative therapy, as well as transport of active agents across biological barriers (cell-membranes, tumor tissue, etc.). 

The surface of any material governs its interactions with the environment. Knowledge over and control of these interaction is especially important when a material is in contact with the biosystem, for example, when applied as transplant, in tissue engineering, in cell cultures, and in blood contact, as weU as in biosensors in medicinal diagnosis, fluids analysis, environmental moititoring, and many other areas. Whereas, on the one hand, the bulk properties of the material are essential for its successful application, for example, as a catheter or a heart valve, special attention has to be paid to render to the surface suitable biocompatible or bioactive properties, no matter of the chemical composition of the bulk material. This is usually achieved by any surface modification process by low molar mass or polymeric compounds. An essential feature of such a modification procedure is the need for a permanent and bioresistant surface finish [87]. 

Magnetic particles have a significant role in nanotechnology due to their surface properties and their applicability in physical and chemical processes like ionic exchange, specific complexation, biocompatibility and bioactivity, capacity of selection and transport for cells and chemical compounds (Safarik Safarikova, 2002). 

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