Bioactive peptides novel

Korhonen, H. and Pihlanto-Leppala, A. 2001. Milk protein-derived bioactive peptides—novel opportunities for health promotion. IDF Bull. 363, 17-26. 

TAKAHASHI M, MORIGUCHI s, YOSHIKAWA M, SASAKI R (1994) Isolation and characterization of oryzatensin a novel bioactive peptide with ileum-contracting and immimomodulating activities derived from rice albumin. Biochem Mol Biol Int. 33 1151-8. 

Neuropeptide S (NPS) is a recently discovered bioactive peptide that has emerged as a new signaling molecule in the complex circuitry that modulates sleep-wakefulness and anxiety-like behavior. The peptide precursor is expressed most prominently in a novel nucleus located in the perilocus coeruleus, a brain structure with well-defined functions in arousal, stress, and anxiety. NPS was also found to induce anxiolytic-like behavior in a battery of four different tests of innate responses to stress. Infusion of NPS potently increases wakefulness and suppresses non-REM (NREM) and REM sleep (Xu et al, 2004). NPS binds to a G-protein-coupled receptor, the NPS receptor, with nanomolar affinity activation of the receptor mobilizes intracellular calcium. The NPS receptor is expressed throughout the brain, particularly in regions relevant to the modulation of sleep and waking, in the tuberomammillary region, lateral hypothalamus, and medial thalamic nuclei. 

Matsui T, Li CH, Osajima Y. (1999) Preparation and characterization of novel bioactive peptides responsible for angiotensin 1-converting enzyme inhibition from wheat germ. J Pept Sci 5 289-297. 

Marine organisms represent a valuable source of nutraceuticals and functional compounds. The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of novel active substances for the development of bioactive products. Recently, a great deal of interest has been expressed in marine-derived bioactive peptides because of their numerous beneficial health effects. Moreover, several studies have reported that marine bioactive peptides can be used as... 

DesMarteau, D. D. Montanari, V. Easy preparation of bioactive peptides from the novel Na-trifluoroethyl amino acids. Chem. Lett. 2000, 1052-1053. 

Food materials, including fish, contain the precursors to these bioactive peptides, which can be formed in vitro or in vivo by enzymatic hydrolysis (Korhonen and Pihlanto 2003). During the past decade, a number of studies have reported on the many physiological properties of these bioactive peptides. The aim of this review is to describe the production of novel peptides derived from marine protein hydrolysates, elucidating the underlying mechanisms of physiological and biofunctional activity that are particular to individual bioactive peptides. The general sources and production of protein hydrolysates will be discussed, followed by a discussion of the nutraceutical properties of protein hydrolysates and their associated bioactive peptides. 

Design and synthesis of novel bioactive peptides and peptidomimetics 03JMC5553. 

Novel foods include those providing protein (soy and dairy), and those that are intended to improve cardiovascular health (stanol esters, P-glucan, bioactive peptides, and n-3 fatty acids), bone and joint health (calcium, glucosamine, and chondroitin), eye health (lutein), the immune system (milkmicronutrients, lactoferrin, lactoperoxidase, and colostrum), gut health (probiotics and prebiotics), body fitness (conjugated linoleic acid, amino acids, and glyco-macropeptide), energy level, and for beauty. 

Smart, D., Preston, C. M. and Lloyd, D. (1990) The use of a novel motility assay for the isolation of bioactive peptides from the free-living nematode Panagrellus redivivus. Comp. Biochem. Physiol. 95B 335-339. 

The anticancer potential of lunasin and soy hydrolyzates studied on leukemia cells (Wang de Mejia, 2007) showed that lunasin-enriched soy flour caused cytotoxicity of leukemia cells. Simulated gastrointestinal hydrolysis of soy protein increased topoisomerase inhibitory activities and cytotoxicity. Such hydrolysates contain hydrophilic, small bioactive peptides (<3 kDa), and three novel topoisomerase inhibitory soy peptides that can be isolated. 

Sato, K, Horibe, K, Amano, K, Mitusi-Saito, M., Hori, M., Matsimaga, S., Fusetani, N., Ozaki, H., Karaki, H., (2001). Membrane permeabilization induced by discodermin A, a novel marine bioactive peptide. Toxicon 39, 259-264. 

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