Bingeing

K. C. Frisch and S. L. Reegen, Bing OpeningPoIjmenyation, Marcel Dekker, Inc., New York, 1969. 

Y. Bing, Monitoring the Progress and the Yield of Solid Phase Organic Reactions Directly On Resin Supports, Acc Chem Res 31 621-630 1998. 

Neu-gelb, n. new yellow massicot, -gestal-bing, /. reorganization modification, -ge-wiirz, n. allspice, pimento, -gier, -gierde, /. curiosity. 

Him Angle Ring Goikot Bolts Head Flat Bing ... 

Anorexia nervosa (AN) and Binge-eating disorder (BED) 1. Increased blood levels of AEA in patients with AN and BED may participate in reward aspects of aberrant eating behaviours 1. None tested... 

Sporadic use (e.g., for the induction of sleep after a psychostimulant binge) does not require specific detoxification. Sustained use can be treated as described in the previous sections on detoxification from therapeutic or high dosages but with added caution. In mixed opioid and benzodiazepine abuse, the patient should be stabilized with methadone (some clinicians use other oral preparations of opioids) and a benzodiazepine. Buprenorphine should not be administered with benzodiazepines, because a pharmacodynamic interaction is possible (Ibrahim et al. 2000 Kilicarslan and Sellers 2000) and fatalities have been reported with the combination (Reynaud et al. 1998). Sedative-hypnotic withdrawal is the more medically serious procedure, and we usually... 

Segal DS, Kuczenski R Behavioral alterations induced by an escalating dose-binge pattern of cocaine administration. Behav Brain Res 88 251—260, 1997 Serper MR, Chou JC, Allen MH, et al Symptomatic overlap of cocaine intoxication and acute schizophrenia at emergency presentation. Schizophr Bull 25 387—394, 1999... 

Feldmann, RJ, Bing DH, Furie BC, Furie B. Interactive computer surface graphics approach to study of the active site of bovine trypsin. Proc Natl Acad Sci USA 1978 75 5409-12. 

The high-dose transition is defined as a transition phase in which the individual suddenly increases the doses of stimulants or switches to smoking (e.g., cocaine crack ) or IV route of administration (Gawin and Ellinwood 1988). This change leads to a rapid escalation of plasma levels and intense euphoria (i.e.. rush) often with subsequent increase in dosing frequency. In its most severe form, the high-dose pattern is characterized by binges of... 

FIGURE 3. Toxicity and development of dependence under single-dose, escalated, and binge conditions... 

The stimulant urge-impulses are seusitive to euviroumeutal cues such as retumiug home aud associated multiple situatioual stimuli (e.g., paraphernalia, friends, etc.). With continued drug availability, it is not unusual to observe repetitious cycles of bingeing with intervening crash and intermediate withdrawal phases over a period of months. It is noted that conditioned withdrawal responses are less pronounced than with opiates yet, withdrawal appears to have a phase-specific relation to the reemergence of cue-sensitive responses that deserves further research. 

During the escalation and bingeing phases of stimulant abuse, higher doses and frequency, as well as propensity for more rapid route of administration, may lead to increased susceptibility to various medical complications. On the other hand, development of either tolerance or sensitization to different stimulant effects is well known (Ellinwood 1973 Post 1981) and should be... 

Effects in Laboratory Animals. As highlighted in other chapters, the central toxicities during and after repeated stimulant bingeing may be related to neuronal or terminal destruction and/or depletion of neurotransmitter in the brain. In monkeys and cats, the report by Duarte-Escalante and Ellinwood (1970) of neuronal chromatolysis associated with decreased catecholamine histofluorescence following chronic METH intoxication has been followed by extensive neurochemical demonstrations of damage to the monoamine pathways by chronic stimulants (Seiden and Ricaurte 1987). 

ANSWER Yes. I am talking about the influence of a subsequent dose on an individual who has had a repetitive binge of amphetamine. At that time, he or she is withdrawn. Then he or she comes back and you can give a relatively low dose that will reinstitute the endstage symptoms, as was being discussed earlier. 

Freed, W.J. Weinberger, D.R. Bing, L.A. and Wyatt, R.J. Neuro-pharmacological studies of phencyclidine (PCP)-induced behavioral stimulation in mice. Psvchopharmacology (Berlin) 71 291-297, 1980. 

Acetaminophen Alcohol binge Allopurinol Amiodarone Cephalosporins (with MTP side chain)... 

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