Cocaine administration

Ahmad K Asia grapples with spreading amphetamine abuse. Lancet 361 1878—1879,2003 Almodovar-Fabregas LJ, Segarra O, Colon N, et al Effects of cocaine administration on VTA cell activity in response to prefrontal cortex stimulation. Ann N Y Acad... 

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Kloss, M.W., Rosen, G.M. and Rauckman, E.J. (1983). Evidence of enhanced in vivo lipid peroxidation after acute cocaine administration. Toxicol. Lett. 15, 65-70. 

Trulson, ME. Babb, S. Joe, J.C. and Raese, J.D. Chronic cocaine administration depletes tyrosine hydroxylase immunoreactivity in the rat nigral striatal system Quantitative light microscopic studies. Exp Neurol 94 744-756, 1986. 

Trulson, ME., and Ulissey. J.J. Chronic cocaine administration decreases dopamine synthesis rate and increases [ H] spiroperidol binding in rat brain. Brain Res Bull 19 35-38, 1987. 

Avakian, E.V., and Manneh, V.A. Cardiac responsivity to epinephrine following chronic cocaine administration. Proc West Pharmacol Soc 30 281-284, 1987. 

Post, R.M. Weiss, S.R.B. Pert, A. and Uhde, T.W. Chronic cocaine administration Sensitization and kindling effects. In Fisher, Raskin, Uhlenhuth, eds. Cocaine Clinical and Behavioral Aspects. Oxford Oxford University Press, 1987. pp. 109-173. 

Henry, D.J., White, F.J. Repeated cocaine administration causes persistent enhancement of D1 dopamine receptor sensitivity within the rat nucleus accumbens. J. Pharmacol. Exp. Ther. 258 882, 1991. 

Hitri A., Little K., Ellinwood D. Effect of cocaine on dopamine transporter receptors depends on routes of chronic cocaine administration. Neuropsychopharmacology. 14 205, 1996. 

Unterwald E.M., Kreek M.J., Cuntapay M. The frequency of cocaine administration impacts cocaine-induced receptor alterations. Brain Res. 900 103, 2001. 

Peris J., Boyson S., Cass W. et al. Persistence of neurochemical changes in dopamine systems after repeated cocaine administration. J. Pharmacol. Exp. Ther. 253 35, 1990. 

Claye L., Akunne H., Davis M., DeMattos S., Soliman K. Behavioral and neurochemical changes in the dopaminergic system after repeated cocaine administration. Mol. Neurobiol. 11 55, 1995. 

Zeigler S., Lipton J., Toga A., Ellison G. Continuous cocaine administration produces persisting changes in the brain neurochemistry and behavior. Brain Res. 552 27, 1991. 

Wallace D., Mactutus C., Booze R. Repeated intravenous cocaine administrations locomotor activity and dopamine D2/D3 receptors. Synapse. 19, 1996. 

Itzhak Y. Differential regulation of brain opioid receptors following repeated cocaine administration to guinea pigs. Drug Alcohol Depend. 3 53, 1993. 

Unterwald E., Rubenfeld J., Kreek M. Repeated cocaine administration upregulates kappa and mu but not gamma opioid receptors. Neuroreport. 5 1613, 1994. 

Spangler R., Bo A., Zhou Y., Maggos C., Yuferov V., Kreek M. Regulation of kappa opioid receptor mRNA in the rat brain by binge pattern cocaine administration and correlation with preprodynorphin mRNA. Mol. Brain Res. 38 71, 1996. 

Richardson N., Roberts D. Fluoxetine pre-treatment reduced breaking points on a progressive ratio schedule reinforced by intravenous cocaine administration in the rat. Life Sci. 49 833, 1991. 

Christensen, J. D., Kaufman, M. J., Frederick, B. et al. Proton magnetic resonance spectroscopy of human basal ganglia response to cocaine administration. Biol. Psychiat. 48 685-692, 2000. 

Perret G, Schluger JH, Unterwald EM, Kreuter J, Ho A, Kreek MJ. (1998). Downregulation of 5-HTlA receptors in rat hypothalamus and dentate gyrus after "binge" pattern cocaine administration. Synapse. 30(2) 166-71. 

Pilotte NS, Mitchell WM, Sharpe LG, De Souza EB, Dax EM. (1991). Chronic cocaine administration and withdrawal of cocaine modify neurotensin binding in rat brain. Synapse. 9(2) 111-20. 

Hemby SE, Co C, Koves TR, Smith JE, Dworkin SI. 1997. Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat. Psychopharmacology (Berl) 133(1) 7-16. 

Pettit HO, Pan HT, Parsons LH, Justice JB Jr. 1990. Extracellular concentrations of cocaine and dopamine are enhanced during chronic cocaine administration. J Neurochem 55(3) 798-804. 

Heimer L, Zahm DS, ChurchUl L, Kalivas PW, Wohltman C (1991) Specificity in the projection patterns of accumbal core and medial shell in the rat. Neuroscience 41 89-125 Hemby SE, No C, Koves TR, Smith JE, Dworkin SI (1997) Differences in extracellular dopamine concentration in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat. Psychopharmacology 133 7-16 Hildebrand BE, Nomikos GG, Hertel P, Sclrilstrom B, Svensson TH (1998) Reduced dopamine output in the nucleus accumbens but not the prefrontal cortex in rats displaying mecamylamine-precipitated nicotine withdrawal syndrome. Brain Res 779 214-225 Ikemoto S (2003) Involvement of the olfactory tubercle in cocaine reward intracranial selfadministration studies. J Neurosd 23 9305-9311... 

A single in vivo cocaine administration abolishes endocannabinoid-depen-dent LTD. This effect of cocaine was not present in mice lacking Di dopamine receptors and was blocked by a selective Di receptor and NMDA receptor antagonist, suggesting the involvement of D i and NMDA receptors (Fourgeaud et al. 2004). 

The assumption that the effects on brain reward mechanisms in animals produced by acute administration of addictive drugs (the brain reward enhancement measured electrophysiologically and the DA enhancement measured neurochemically in Acb) has relevance to self-reported euphoria at the human level is supported by real-time, in-vivo, positron emission tomography studies of DA transporter occupancy in human brain loci following acute cocaine administration (Volkow et al. 

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