Binding compounds

The linking of two weaker binding compounds may lead to strong binding one, primarily due to the saving of one entropical factor if both original compounds are chemically connected ... 

Sekiguchi, N., Yata, M., Murata, M., Homma, S., Identification of an iron-binding compound in instant coffee, 2, Nippon Nogei Kagaku Kalsh, 68(4), 821, 1994. (CA120 321801d)... 

Violette SM, Shakespeare WC, Bartlett C, Guan W, Smith JA, Rickies RJ, Bohacek RS, Holt DA, Baron R, Sawyer TK. A Src SH2 selective binding compound inhibits osteoclast-mediated resorption. Chem Biol 2000 7 225-235. 

Fox MP, McKinlay MA, Diana GD, Dutko FJ. Binding affinities of structurally related human rhinovirus capsid binding compounds are related to their activities against human rhinovirus type 14. Antimicrob Agents Chemother 1991 30 110-116. 

We have made quantitative measurements of the binding of organic compounds to dissolved humic and fulvic acids. The extent of binding increases as a compounds octanol/water partition coefficient increases or as its water solubility decreases. Humic acids bind compounds to a greater extend than fulvic acids, but there are large differences between different humic and fulvic acids. 

Unfortunately there is also some bad news for modelers. Different humic materials bind compounds to dramatically different extents, and the reasons for this are unclear. Figure 6 shows the binding constants of DDT to seven different humic materials. Some of this data is from a factorial experiment which has been published elsewhere.7 Inspection of this data shows that the humic acids and the... 

Park et al." used U-4CR libraries to prepare Ras-Raf protein-binding compounds like 30 that are active against HIV. The patented product 31 has been formed by Lockhoft at the Bayer AG using a U-4CR of four different protected glucose derivatives that were later deprotected. The product 32 of... 

Table 2.3 GPC spin column/ESI-MS non-covalent binding studies of RNA with model RNA and DNA binding compounds (intercalators).

MS multiple compounds in solution target in solution ligands and subjected to centrifugal ultrafiltration binding compounds separated from non-binders that are washed to waste ligands bound to target are eluted by acidification and detected by MS Zweigenbaum, Henion, 1997)... 

Klekota, B. Hammond, M. H. Miller, B. L. Generation of novel DNA-binding compounds by selection and amplification from self-assembled combinatorial libraries. Tetrahedron Lett. 1997, 38, 8639-8643. 

Klekota, B. Miller, B. L. Selection of DNA-binding compounds via multistage molecular evolution. Tetrahedron 1999, 55, 11687 (Combinatorial Chemistry Symposium in Print). 

Figure 3.15 Components of (CUG) RNA-binding compounds identified by RBDCC.

Ratledge C, Patel PV (1976) The Isolation, Properties and Taxonomic Relevance of Lipid-soluble, Iron-binding Compounds (the Nocobactins) from Nocardia. J Gen Microbiology 93 141... 

Ratledge C, Snow GA (1974) Isolation and Stmcture of Nocobactin NA, a Lipid-soluble Iron-binding Compound from Nocardia asteroides. Biochem J 139 407... 

We describe how we prepared and characterized gold nanoparticles ( 3 nm in diameter) capped with thiolated cyclodextrins. The CD-capped nanoparticles are hydrophilic, and they bind compounds derivitized from ferrocene as evidenced by values measured by NMR spectroscopy. (Adapted from Liu et al., 2001)... 

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