Platinum compounds, nucleic acid binding

Binding of Platinum Compounds to Monomeric Nucleic Acid Fragments. 65... 

Spectroscopic and crystallographic studies of platinum-base complexes give some insight into the reactivity of the platinum compounds and their possible binding sites on DNA. The reactions of the different nucleosides or nucleotides with the chloro and aquo derivatives of O Cs- and trans-DDP have been studied by UV spectroscopy (36), raman difference spectrophotometry (37) and high pressure liquid chromatography (38). For both chloro isomers, the rates of the reactions with various nucleic acid monomers show the following trend GMP > AMP > CMP and dG > dA > dC T, The dichloro and diaquo derivatives react slowly with thymidine and UMP (37) or not at all (38, 39). 

Finally, the appearance of more reviews of platinum-containing anticancer agents reflects the enormous amount of work devoted to this sub-ject. Features of chemical interest in them include the effects of leaving group (in substitutions), solubility and electronic charge, and the nature of the binding of platinum compounds to nucleic acids. 

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