Binding of CO to Myoglobin, Hemoglobin, and Model Compounds

Not only is carbon monoxide produced during catabolism of hemes, but it is also necessary for maintenance of neuronal function and cell signaling in the vasculature and therefore is present normally in the vicinity of Mb and Hb. For synthetic systems of picket-fence, pocket, or capped porphyrins, CO affinity exceeds that for O2 sometimes by many orders of magnitude. The in 

In attempting to understand how the attachment and release of carbon monoxide, and ultimately dioxygen, happens on a molecular scale, Rodgers 

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