Beta-cell apoptosis

Kurrer, M. O., Pakala, S. V., Hanson, H. L. and Katz, J. D. (1997). Beta cell apoptosis in T cell-mediated autoimmune diabetes. Proc. Natl. Acad. Sci. USA 94, 213-218. 

M. Shimabukuro, Y.T. Zhou, M. Levi, and R.H. Unger, Fatty acid-induced beta cell apoptosis a link between obesity and diabetes, Proc. Natl. Acad. Sci. USA,... 

Maedler K, Carr RD, Bosco D, Zuelhg RA, Bemey T, Donath MY. Sulfonylurea induced beta-cell apoptosis in cultured human islets. J Clin Endocrinol Metah 2005 90(l) 501-506. 

Beta-cell apoptosis 4> beta-cell replication ba Beta-cell apoptosis b Beta-cell mass 4 t ... 

Li Y, Hansotia T, Ynsta B, Ris E, Halban PA, Drucker DJ. Glucagon-hke peptide-1 receptor signaling modnlates beta cell apoptosis. J Biol Chem 2003 278 471-478. 

Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003 52 102-110. 

Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC. Sustained beta cell apoptosis in patients with longstanding type 1 diabetes indirect evidence for islet regeneration Diabetologia. 2005 48 2221-2228. [Epub 2005 Oct 5.]... 

Bregenholt S, Moldrup A, Blume N, Karlsen AE, Nissen Friedrichsen B, Tomhave D, et al. The long-acting glucagon-like peptide-1 analogue, hraglutide, inhibits beta-cell apoptosis in vitro. Biochem Biophys Res Commun. 2005 330 577-584. 

Butler AE, Janson J, Soeller WC, Butler PC. Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes evidence for role of islet amyloid formation rather than direct action of amyloid. Diabetes. 2003 52(9) 2304-2314. 

Freemerman AJ, Turner AJ, Birrer MJ, Szabo E, Valerie K, Grant S (1996) Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C. Mol Pharmacol 49 788-795 Freund A, Boos J, Harkin S, Schultze-Mosgau M, Veerman G, Peters GJ, Gescher A (1998) Augmentation of l-beta-D-arabinofuranosylcytosine (Ara-C) cytotoxicity... 

GLP-1 increases beta-cell mass in animals. Thus, exenatide has the potential to cause increased beta-cell mass through augmented differentiation of precursor cells and inhibition of apoptosis (9). No malignant islet cell tumors were found in 130 mice and rats who received the... 

Insulin-dependent diabetes mellitus (IDDM) is an example of a metabolic disease under active consideration for inducible gene therapy strategies. In this disorder, inflammatory cytokines have been shown to activate apoptosis in pancreatic beta cells. Experimental studies indicate that expression of insulinlike growth factor-1 (IGF-1) can prevent the cytokine-mediated destruction of beta cells of the pancreas (Giannoukakis et al., 2001). Regulated expression of IGF-1 in human pancreatic islets, to preserve beta cell function, may be a useful approach in the treatment of certain types of diabetes (Demeterco and Levine, 2001). 

Giannoukakis, N., Mi, Z., Rudert, W.A., Gambotto, A., Trucco, M. and Robbins, P. (2001) Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I. Gene Ther., 7, 2015-2022. 

Liu, Y., Rabinovitch, A., Suarez-Pinzon, W., Muhkeijee, B., Brownlee, M., Edelstein, D. etal. (1996) Expression of the bcl-2 gene from a defective E1SV-1 amplicon vector protects pancreatic beta-cells from apoptosis. Hum. Gene Ther., 7, 1719-1726. 

Dihydroceramide exhibits different physical and biochemical effects compared with the corresponding ceramide bearing the same A-acyl chain. For example, channel formation in mitochondrial membranes (78) and protein phosphatase activity in pancreatic beta cells are inhibited by dihydroceramide but are activated by ceramide (63, 79). Dihydroceramide is less effective than ceramide in inducing apoptosis (68). 

Efanova IB, Zaitsev SV, Zhivotovsky B, Kohler M, Efendic S, Orrenius S, Berggren PO. Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca + concentration. J Biol Chem 1998 273(50) 33501-33507. 

Raile, K, Berthold, A, Banning, U, Horn, F, Pfeilfer, G, and Kiess, W, Igfs, basic fgf, and glucose modulate proliferation and apoptosis induced by ifngamma but not by il-lbeta in rat ins-le beta-cells. Harm Metab Res, 2003. 35(7) 407-414. 

Ritzel, RA and Butler, PC, Replication increases beta-cell vulnerability to human islet amyloid polypeptide-induced apoptosis. Diabetes, 2003. 52(7) 1701-1708. 

Wrede, CE, Dickson, LM, Lingohr, MK, Briaud, I, and Rhodes, CJ, Protein kinase b/akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (ins-1), J Biol Chem, 2002. 277(51) 49676-49684. 

Kaneto, H., Fujii, J., Myint, T. et al. Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction. Biochem J 1996 320(Pt 3) 855-63. 

Rakatzi, 1 Mueller, H Ritzeler, O Tennagels, N Eckel, J. Adiponectin counteracts cytokine- and fatty acid-indueed apoptosis in the pancreatic beta-cell line INS-1. 

Chen J, Fontes G, Saxena G, Poitout V, Shalev A. 2010. Lack of TXNIP protects against mitochondria-mediated apoptosis but not against fatty acid-induced ER stress-mediated beta-cell death. Diabetes 59 440447. 

Ishizuka, N, Yagui, K, Tokuyama, Y, Yamada, K, Suzuki, Y, Miyazaki, J, Hashimoto, N, Makino, H, Saito, Y and Kanatsuka, A (1999) Tumor necrosis factor alpha signahng pathway and apoptosis in pancreatic beta cells. Metabolism, 48, 1485-1492. 

The insulinotropic property was also attributed to lauric acid from coconut oil in vitro experimental conditions, with isolated islets of mice. The synergic effect of the lauric acid combined with the polyphenolie eontent of the eoconut oil offer a reduction in blood sugar. When the lauric acid is in the same percent, the hot extracted virgin coconut oil appears to have a better hypoglycemic effect, compared to the cold extracted virgin coconut oil. The result offers a good perspective on the protective effect of the polyphenolie compounds found in the two oils on pancreatic beta cells from apoptosis (Siddalingaswamy et al., 2011). 

S. Increased synthesis of transforming growth factor-beta , which blocks cell division and promote.s apoptosis by interacting with its own membrane recepror,... 

Transforming growth factor-beta (TGF- 3) proteins are multifunctional morphogens that control cell proliferation, differentiation and apoptosis, as well as cell migration and immune surveillance. TGF-(3 acts as a tumor suppressor, but can also act as a tumor promoter in... 

HASHIMOTO S, XU M, MASUDA Y, AIUCHI T, NAKAJO S, CAO J, MIYAKOSHI M, IDA Y and NAKAYA K (1999) Beta-hydroxyisovalerylshikonin inhibits the cell growth of various cancer cell lines and induces apoptosis in leukemia HL-60 cells through a mechanism different from those of Fas and etoposide , J Biochem (Tokyo), 125 17-23. 

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