Behcet’s disease

This is a chronic inflammatory disease, which can affect the gut as well as other organs. There is relatively little information on the role of free radicals in this condition. Neutrophil chemiluminescence was increased in patients with intestinal Behcet s compared to normal controls (Suematsu et al., 1987a) and there is some evidence for endothelial injury by neutrophil-derived oxidants (Niwa et al., 1982). Preliminary studies with lip)osomal-encapsulated SOD demonstrated marked improvement in 12 out of 16 pjatients wdth active Behcet s disease (Niwa etal., 1985). 

Ertenli I, Kiraz S, Calguneri M, et al. Synovial fluid cytokine levels in Behcet s disease. Clin Exp Rheumatol 2001 19(5 Suppl 24) S37 11. 

The autoimmune rheumatic diseases consists of Rheumatoid Arthritis (RA), Spondylarthritis (SpA), Systemic Lupus Erythematosus (SLE), Polymyositis, Dermatomyositis, Polymyalgia Rheumatica, Acute Temporal Arteritis, Giant Cell Arteritis, Behcet s Disease, Sjorgren s Syndrome, Felty s Syndrome and Mixed Connective Tissue Disease (MCTD). Spondylarthritis (SpA) can be subdivided in Reactive Arthritis (ReA), Ankylosing Spondylitis (AS), Psoriatic Arthritis (PsA), Arthritis associated with the inflammatory bowel diseases are Crohn s disease and Ulcerative Colitis (IBD), Undifferentiated SpA (UspA) and Sacro-ilitis, Juvenile SpA and Acute Anterior Uveitis (AAU). 

Dermatological system (erythroderma, icthyosis, Stevens-Johnson syndrome, Behcet s disease, acute blistering diseases)... 

Siikakis PP. 2002. Behcet s disease A new target for anti-tumour necrosis factor treatment. Ann Rheum Dis. 61 ii51-u56. 

Primary systematic vasculitis Rheumatoid disease Sjogren s syndrome Behcet s disease... 

Neurological involvement in Behcet s disease may be subclassified into two major forms a vascular-inflammatory process with focal or multifocal parenchymal involvement and a cerebral venous sinus thrombosis with intracranial hypertension. The vasculitis and meningitis may affect cerebral arteries, particularly in the posterior circulation, to cause ischemic stroke and possibly intracranial hemorrhage (Farah et al. 1998 Krespi et al 2001 Siva et al. 2004 Borhani Haghighi et al. 2005). 

Subarachnoid hemorrhage due to septic embolic infarction in infective endocarditis. Cerebrovascular Diseases 9 182-184 Krespi Y, Akman-Demir G, Poyraz M et al (2001). Cerebral vasculitis and ischemic stroke in Behcet s disease report of one case and review of the literature. European Journal of Neurology 8 719-722... 

Behcet s disease (+) HLA-B5 or (-) BW51 — Internist, rheumatologist Behget s skin puncture test... 

Niino M, Ogata A, Kikuchi S, Tashiro K, Nisliihira J (2000) Macrophage migi adon inliibitory factor in die cerebrospinal fluid of padents widi convendonal and opdc-spinal forms of muldple sclerosis and neuro-Behcet s disease. J Neurol Sci 179 127—131. 

Bayraktar, Y., Balkanci, F., Bayraktar, M., Calguneri, M. Budd-Chiari syndrome a common comphcation of Behcet s disease. Amer. J. Gastroenterol. 1997 92 858 -862... 

Yamamoto JH, Minami M, Inaba G, Masuda K, Mochizuki M (1993) Cellular autoimmunity to retinal specific antigens in patients with Behcet s disease. Br J Ophthalmol 77 584—589. 

Gonzalez-Escribano NF, Morales J, Garcia-Lozano JR, Castillo MJ, Sanchez-Roman J, Nunez-Roldan A, Sanchez B (1995) TAP polymorphism in patients with Behcet s disease. Ann Rheum Dis, 54 386-388. 

Chlorambucil (0.1 to 0.2 mg/kg/d for 3 to 6 weeks) will provide palhation in chronic lymphocytic leukemia, mahg-nant lymphomas including lymphosarcoma, giant follicular lymphoma, and Hodgkin s disease. In addition, it has been used in the treatment of uveitis and meningoencephalitis associated with Behcet s disease. Chlorambucil is absorbed orally, metabolized extensively, and the metabolite is... 

Nervous system Cerebral tumor-like lesions, uncommon in Behcet s disease, have been reported in a man taking ciclosporin who developed a lymphocytic meningitis and relapsed after rechallenge [8 ]. 

Behcet s disease (BD) is a multisystem disease characterized by mucocutaneous, ocular, articular, vascular, intestinal, urogenital, and neurologic involvement. BD was first described as a triad of recurrent aphthous stomatitis, genital aphthae, and relapsing uveitis in 1937 by Hulusi Behget, a Turkish dermatologist (1), but descriptions of the disease features date back to Hippocrates, from his third book of epidemiology written in the fifth century BC. 

Table 1 Frequency of Clinical Manifestations in Behcet s Disease...

International Study Group for Behcet s Disease. Criteria for diagnosis of Behfet s disease. Lancet 1990 335 1078-1080. 

Ning-Sheng L, Chun-Liang L, Ray-Sheng L. Bronchiohtis obhterans organizing pneumonia in a patient with Behcet s disease. Scand J Rheumatol 2004 33(6) 437-440. 

Guney E, Akcali G, Akcay BI, Urdu C, Erdogan G, Bozkurt TK, et al. Vitiligo in a patient treated with interferon alpha-2a for Behcet s disease. Case Reports Med 2012 3. Article ID 387140. http //dx.doi.org/10.1155/2012/387140. 

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