Recurrent aphthous stomatitis

Ulcerating lesions Topical treatment of ulcerating lesions of the oral cavity, such as recurrent aphthous stomatitis (canker sores). 

Aphthae, recurrent aphthous stomatitis, periodontitis, gastritis, constipation. 

Levamisole has been used in the treatment of recurrent aphthous stomatitis (2) and its value reviewed (3). In four of seven placebo-controlled studies there was a reduction... 

Amanlou, M., Babaee, N., Saheb-Jamee, M. et al. 2007. Ef cacy of Satureja khuzistanica extract and essential oil preparations in the management of recurrent aphthous stomatitis. Dam 15 231-234. 

Mansoori, R, Hadjiakhondi, A., Ghavami, R., Sha ee, A. 2002. Clinical evaluation of Zataria multiflora essential oil mouthwash in the management of recurrent aphthous stomatitis. Daru 10 74-77. 

Colchicine with its microtubule-disrupting properties limits the chemotactic and phagocytic activity of polymorphonuclear lymphocytes. It also induces the release of prostaglandin E, a suppressor of leukocyte function by increasing the level of cyclic adenosine monophosphate [39]. Furthermore, the ability of colchicine in inhibition of IL-1 production and histamine release makes it an excellent drug for a number of dermatitis-related complexities like psoriasis, Behget s syndrome, recurrent aphthous stomatitis, leukocytoclastic vasculitis and urticarial vasculitis, bullous disease, scleroderma, fibromatosis. Sweet s syndrome, amyloidosis, and many more [40]. 

Behcet s disease (BD) is a multisystem disease characterized by mucocutaneous, ocular, articular, vascular, intestinal, urogenital, and neurologic involvement. BD was first described as a triad of recurrent aphthous stomatitis, genital aphthae, and relapsing uveitis in 1937 by Hulusi Behget, a Turkish dermatologist (1), but descriptions of the disease features date back to Hippocrates, from his third book of epidemiology written in the fifth century BC. 

Stomatitis is a troublesome adverse effect of DMARDs. Ulcers of the oral mucosa are not uncommon in patients taking penicillamine (188,173) and lead to withdrawal in 3.1% of patients (174). However, stomatitis may be a consequence of multiple factors, including hematinic deficiency, virus or Candida infection, recurrent aphthous ulceration, or Sjogren s syndrome. Moreover, aphthous stomatitis often occurs in users of non-steroidal antiinflammatory drugs (175). 

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