Base fibroblast growth factor

THE MOLECULAR BASES OF THE CHONDRODYSPLASIAS INCLUDE MUTATIONS IN GENES ENCODING TYPE II COLLAGEN FIBROBLAST GROWTH FACTOR RECEPTORS... 

Tsai TT et al (2007) Fibroblast growth factor-2 maintains the differentiation potential of nucleus pulposus cells in vitro implications for cell-based transplantation therapy. Spine (Phila Pa 1976) 32(5) 495-502... 

One key NMR-based study has focused on the evaluation of the dynamic properties of heparin-like hexasaccharides.20 The analysis of Tj, T2 and NOE 13C-NMR data of biologically active synthetic compounds has shown that the sulphation pattern strongly influences the internal dynamics, and supports the importance of the GAGs flexibility on the selectivity of the interaction with fibroblast growth factors. 

Heparin has been used in enzyme purification such as recombinant human mast cell tryptase. The purified enzyme is fully active [12]. Heparin-based affinity chromatography also permitted the isolation of growth factors such as basic fibroblast growth factor (bFGF). The affinity is lower when bFGF is complexed with acidic gelatin [13]. The elution of synthetic TFPI (tissue factor pathway inhibitor) peptidic fragments on immobilized heparin has allowed one to find the peptidic sequence responsible for the TFPI-heparin interaction [14]. 

Adenovirus-based Gene Therapy Therapeutic Angiogenesis with Adenovirus 5 Fibroblast Growth Factor-4 (Ad5FGF-4) in Patients with Chronic Myocardial Ischemia... 

Raz, V. Kelman, Z. Avivi, A. Neufeld, G. Givol, D. Yarden, Y. PCR-based identification of new receptors molecular cloning of a receptor for fibroblast growth factors. Oncogene, 6, 753-760 (1991)... 

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