Synthetic biologically active

I.4.I.4. Synthetic Biologically Active Compounds Silyl- and carbonyl-substituted isoxazoles have been prepared and screened for their cytotoxic activity (497). Some exhibited moderate cytotoxicity toward the HT-1080 and MG-22A cell lines. The highest activity level has been displayed by 3-methyl-5-diphenyl-methylsilylisoxazole. 

Building blocks derived from microbial transformations are usually employed as the key units of fluorinated analogs of appropriate natural products or synthetic biologically active materials [42-45]. Among such useful compounds, trifluoromethylated carbohydrates constitute one of the most interesting fields for intensive study. Novel and efficient routes to access a variety of chiral... 

In this exciting context, this volume provides a broad overview on the field of synthetic biologically active surfaces. In particular, three important aspects are emphasized in this volume (1) surface design, (2) interactions of 2D and 3D surfaces with biosystems, and (3) applications. Regarding surface preparation and modification, the reader will find in this book a practical description of synthetic tools, which constitute the state of the art in the field. For instance, surface functionalization... 

Chiral non-racemic cyclopropanes are a common motif in natural and synthetic biologically active compounds [85]. They represent an important target in asymmetric synthesis, and a range of catalytic methods have been developed for their synthesis [6, 47, 86-90]. Many of the existing methods make use of a chiral metal complex as catalyst [6], but organocatalytic methods have also been developed. In this section we will review methods using a substoichiometric amount of a chiral ylide as a catalyst for cyclopropanation [91]. 

The current volume of "Studies in Natural Products Chemistry" represents a departure from the earlier volumes which were focused on structure and synthetic aspects of natural product chemistry. From Volume 21 onwards this series of books will be dedicated to bioactive natural products and it will comprise state-of-art review articles written by eminent experts on structural, synthetic, biological activity as well as biosynthetic studies relating to bioactive natural products. The series should therefore be of particular interest to medicinal chemists working in universities and pharmaceutical companies. 

These five-membered rings with two nitrogen atoms (95) are present in many natural products and many synthetic biologically active compounds. The obvious disconnection gives a 1,2-dicarbonyl compound, an acid, and two molecules of ammonia. 

ACID-TREATMENT OF ARYLPROPANOID AND ARYLETHANOID DERIVATIVES - ACCESS TO NATURAL AND SYNTHETIC BIOLOGICALLY ACTIVE POLYPHENOLS... 

Donaruma, L.G. (1974) Synthetic biologically active polymers. Prog. Polym. Sci. 4 1-25. 

The pyrrolidine ring is found abundantly in both naturally occurring and synthetic biologically active compounds. The alkaloid nicotine, an agonist for the nicotinic acetylcholine receptor, is a notorious example of the former. Pyrrolidine itself is found in carrot and tobacco leaves. The prevalence of pyrrolidines in bioactive compounds has led to much interest in the development of flouropyrrolidine building blocks. The... 

Samour, C. M. Polymeric drugs in the chemotherapy of microbial infections in ref. 229, p. 161 Donaruma, L. G. Synthetic Biologically Active Polymers Progress in Polym. Sci. 4, London, Pergamon 1975... 

The state of the subject up to the early 1960 s is covered by the volume edited by Fettes. Several collections of articles on reactions of polymers have been published since then, " as well as specialized reviews on particular topics including syntheses on solid supports, reactions on unsaturated polymers, and synthetic biologically active polymers. ... 

It is interesting that the retrosynthetic approach to heterocycles is not considered in monographs or review articles on the synthesis of individual classes of heterocyclic compounds. The examples that follow illustrate the retrosynthetic approach to the five- and six-membered heterocyclic structures often encountered in natural or synthetic biologically active compounds. Examples 7.2, 7.3, 7.6, 7.11 and 7.12 demonstrate syntheses of biologically active compounds developed to large-scale production by chemists at PLIVA Co. (Croatia). 

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