B-Cell Neoplasia

CD19 +, CD20 +, CD22 +, CD74 +, CD79a +, PAX-5 +, bcl-2 +,CD5 -/+, CDIO CD23 CD43 Cyclin D1 — 

CD43 —, k/X light chain restriction —/+ Proliferation index [Ki-67 (MIB-1) index] in bcl-2-positive neoplastic follicles 15% 

---

Because of reports of severe adverse effects, the presence of rheumatoid factor in patients with B cell neoplasia may constitute a contraindication to intravenous immunoglobulin (83). 

BCMS Contains regions frequently deleted in B cell neoplasia... 

B-cell neoplasia-associated gene with multiple splicing 216 Bcl-2 317... 

Vol. 246 Melchers, Fritz Potter, Michaei (Eds.) Mechanisms of B Cell Neoplasia 1998. 1999. Ill figs. XXIX, 415 pp. 

Vol. 252 Potter, Michael Melchers, Fritz (Eds.) B1 Lymphocytes in B Cell Neoplasia. 2000. XIII, 326 pp. 

K9. King, B. E., Chen, C., Locker, J., Kant, J., Okuyama, K., Falini, B., and Swerdlow, S. H., Immunophenotypic and genotypic markers of follicular center cell neoplasia in diffuse large B-cell lymphomas. Mod. Pathol. 13, 1219-1231 (2000). 

FIGURE 16.40 Placenta-like alkaline phosphatase immunoex-pression in intratubular germ cell neoplasia (IGCNU) (A and B). Infiltrating classic seminoma cells are also positive (C). 

Kim, B., van Golen, C.M., and Feldman, E.L., Degradation and dephosphorylation of focal adhesion kinase during okadaic acid-induced apoptosis in human neuroblastoma cells, Neoplasia, 5, 405, 2003. 

Kumar, A.P., Garcia, G.E., Ghosh, R., Rajnarayanan, R.V., Alworth, W.L., and Slaga, T.J., 4-Hydroxy-3-methoxybenzoic acid methyl ester a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway potential for prostate cancer management. Neoplasia, 5 (3), 255-266, 2003. 

Follicular lymphoma, B-cell lymphoma, plasma cell neoplasia, hepatocellular carcinoma, placental site trophoblastic tumor, rhabdomyosarcoma, Ewing s sarcoma... 

Faltus T, Yuan J, Zimmer B, Kramer A, Loibl S, Kauftnann M, et al. Silencing of the HER2/neu gene by siRNA inhibits prohferation and induces apoptosis in HER2/neu-overexpressing breast cancer cells. Neoplasia 2004 6 786 95. 

The clinical presentation of patients with endocrine pancreatic tumors will vary according to the type of hormone released. Hyperinsulinism manifested with diarrhea, abdominal pain, and low levels of glucose will be found in the majority of patients. Nesidioblastosis is a primitive pancreatic B cells hyperplasia. Approximately 5% of patients with hyperinsulinism may have this type of tumor. Hunger, jitteriness, lethargy, apnea, and seizures are common manifestations in newborns with nesidioblastosis, while older children may show diaphoresis, confusion, or unusual behavior. Zollinger-Elli-son syndrome will present with intractable peptic ulcers. Patients with vipomas will have watery diarrhea, hypokalemia, and achlorhydria, while multiple endocrine neoplasias have been reported with multiple endocrine neoplasia type 1 (MEN 1). 

FIGURE 14 Doxorubicin (DXR) plasma concentration (pg/mL) as function of time from dosing (a) C57BL/6 mice inoculated (by intraveneous injection) with B16F10.9 cells (b) healthy C57BL/6 mice (c) BALB/c mice inoculated with C-26 cells (injected into right-hind footpad). A single dose of the selected formulation was injected into the tail vein. DXR formulations and doses are specified. (Reprinted from ref. 443 with permission of Neoplasia Press, Inc.)... 

The 12% of lymphoma and 10% of chronic lymphatic leukemia with paraproteins may actually represent neoplasia of the B-lymphocyte line (bursa-equivalent), i.e., true plasma cell precursors. The prognosis... 

Clarkson, R. W. E., and Watson, C. J. (1999) NF-kappa B and apoptosis in mammary epithelial cells. J. Mammary Gland Biol. Neoplasia 4,165-175. 

Engl T., Relja B., Marian D., et al. (2006) CXCR4 chemokine receptor mediates prostate tumor cell adhesion through alpha5 and beta3 integrins. Neoplasia. 8, 290-301. 

Chiavegato A, Bochaton-Piallat M-L, D Amore E, Sartore S, Gabbiani G (1995) Expression of myosin heavy chain isoforms in mammary epithelial cells and in myofibroblasts from different fibrotic settings during neoplasia. Virchows Archiv B 426 77-86... 

---