Markers genotyped

Tryptase is at the present moment the main clinical marker for anaphylaxis and mastocytosis. There are two major human mast cells tryptases, a- and (3-tryptase, encoded by two genes located at chromosome 16. The haploid genotype for tryptase is (3a or (3(3.25% of individuals are a-tryptase-deficient a-tryptase shows a 90% amino acid sequence identity with (3-tryptase. 

Analysis in diverse lines can facilitate identification of useful alleles that control expression of enzymes upstream of the carotenoid pathway, a feature that would not be evident from conventional end-product screening of breeding lines. Moreover, this characterization sets the stage for marker-assisted selection of superior endogenous alleles and facilitates selection of introduced transgenes that may be necessary to supplement the genotypic contribution required for a particular plant chemical outcome. 

Zhang, L.H., Chai, J.J., Jiao, W., Osman, Y. and McManus, D.P. (1998) Mitochondrial genomic markers confirm the presence of the camel strain (G6 genotype) of Echinococcus granulosus in north-western China. Parasitology 116, 29-33. 

In a genome-wide scan study, a large proportion of the genotyped markers fall into intergenic regions, and are likely to be not relevant for association studies. 

Research underway by our group and others on the clinical pharmacogenomics of depression is focused on identifying genetic markers as positive and negative predictors of treatment response. It is necessary that rigorous clinical studies be performed in order to examine closely the relation between genotype and the phe-... 

A family in which a mutahon causing neurofibromatosis type 1 is transmitted in three generations. The genotype of a marker locus is shown for each pedigree member. 

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