Aureomycin - Chlortetracycline

My association with antibiotics in livestock feeds started in 1949 when Dr. Robert Stokstad and I found that aureomycin mash increased the growth of young chickens that received a complete diet., The growth-promoting effect of aureomycin (chlortetracycline) was announced at the American Chemical Society meetings in Philadelphia, April 1950. 

Aureomycin (chlortetracycline hydrochloride) Sugars Streptomyces aureofaciens... 

Aureomycin (Lederle)-comb. with chlortetracycline Biofanal (Pfleger)... 

The current official FDA Chlortetracycline Working Standard is chlortetracycline hydrochloride, Lot //501-632B-95-1 (9/29/53), obtained from Lederle, which markets the antibiotic under the proprietary name Aureomycin. The current working standard has an assigned potency of 1000 yg/mg (the term yg applied to chlortetracycline means the chlortetracycline activity (potency) contained in 1 yg of the FDA Chlortetracycline Master Standard (Lot 990-107-141-1), which is also chlortetracycline hydrochloride). 

Important tetracyclines include chlortetracycline (Aureomycin) and oxytetracycline (Terramycin). Tetracyclines are broad-spectrum antibiotics, which means that they... 

Tetracycline (SUBAMYCIN) Oxytetracycline (TERRAMYCIN) Chlortetracycline (AUREOMYCIN) Demeclocycline (LEDERMYCIN) Doxycycline (BIODOXI) Minocycline (CANOMYCIN)... 

Aureomycin (Lederle)-comb. with chlortetracycline Biofanal (Pfleger) Candio-Hermal (Hermal) Candio-Hermal (Hermal)-comb. with chlortetracycline Fungireduct (Azupharma) Halog (Bristol-Myers Squibb)-comb. 

Tetracyclines. In 1948, a broad-spectrum antibiotic, chlortetracycline (Aureomycin), was introduced by the Lederle Laboratories, a... 

Chlortetracycline Hydrochloride. USP. Chlonctracy-dine (Aureomycin hydrochloride) was isolated by Dug-gar"" in 194S from S. uiireofaciens. This compound, whith was produced in an cxtcn.sivc. search fur new antibiotics, was the first of the group of highly successful tetracyclines. It soon became established as a valuable antibiotic with broad-spectrum activities. 

Chlorquinaldol [ban, inn] (Capitrol ) is a hydroxyquino-line ANTIBACTERIAL and ANTIFUNGAL topical agent, which can be used to treat dandruff and seborrhoeic dermatitis, chlortalidone chlorthalidone, chlortetracycline [ban, inn] (chiortetracycline hydrochloride [usan] aureomycin Aureomycin ) Isa (tetracycline) ANTIBIOTIC. It can be used clinically as a broad-spectrum, normally topical, ANTIBACTERIAL to treat a variety of infections. 

In 1948, Benjamin M. Duggar (1872-1956), a professor at the University of Wisconsin and a consultant to Lederle, isolated chlortetracycline from Streptomyces aureofaciens. Chlortetracycline, also called aureomycin, was the first tetracycUne antibiotic and the first broad-spectrum antibiotic. Active against various organisms, aureomycin works by inhibiting protein synthesis. The discovery of the tetracychne ring system also enabled further development of other important antibiotics. Since that time more than a hundred molecules active against a wide range of bacteria have been discovered. 

The epoch-making discovery of chlortetracycline (aureomycin) in 1947 by Duggar paved the way for a number of structural analogues used as broad-spectrum antibiotics that belong to the tetracycline family. The tetracyclines which are found to be effective therapeutically are listed in the following table. 

The ability to produce antibiotics is common among the actinomycetes and much of the interest in these filamentous bacteria in recent years may be attributed to this fact. This interest has been manifest chiefly in research connected directly or indirectly with medicine. Soil samples from all over the world have been examined in the search for new species and strains that may produce a new antibiotic suitable for medical use. Hundreds of these antibiotics have been isolated but only a few have been found to be sufficiently non-toxic and specific for use in disease control. Among the best known of these that are in use are streptomycin, terramycin, aureomycin, cycloheximide, chlortetracycline, oxytetracycline, chloramphenicol and neomycin. Some of these have been used to a limited extent in disease control in plants. Their use for this purpose is limited by cost, by difficulty in getting the antibiotic into the plant, and by toxicity when used at concentrations adequate to be effective. The limited time that they are effective is also an important factor (Brian, 1957 Zaumeyer, 1958 Pramer, 1959). The role of antibiotics in soils and their effect on microbial ecology is considered in Chapter 18. 

Contact allergy to tetracyclines appears to be rare. Aureomycin ointment (Lederle) produced a dermatitis in a woman who applied the ointment to an area treated by dermabrasion. The patient was positive to chlortetracycline and di-methylchlortetracycline, but negative to oxytetracycline, tetracycline, and cymety-cline (Calnan 1967). Bojs and Moller (1974) reported three patients with contact allergy to oxytetracycline. Cross-sensitivity to tetracyclin and methacycline was demonstrated in two of the cases. 

Chlortetracycline (Aureomycin) is The Minimum Inhibitory Concentrate Clindamycin is ... 

Inhibitory Zone Diameter for Chlortetracycline (Aureomycin) concentration (disc) 5 yg is mm. 

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