Asparagine, growth inhibition

Mirixins A, B, and C (Fig. 57) were isolated from an ethyl acetate extract of marine bacterium Bacillus sp., obtained from sea mud near the Arctic pole by Zhang et al. in 2004. Mirixins contain three asparagine residues and the P-amino fatty acyl side chains. Mirixins A, B and C exhibit growth inhibition with IC50 values of 0.68, 1.6 and 1.3p.g/ml, respectively against HCT-116 human colon tumor cells ... 

Humulus lupulus L. She Ma (Hop) (female flower, unripe fruit) Humulone, resin, lupulone, choline asparaginer, lupulin, isohumulone, isovaleric acid.33-450 This herb is toxic. Inhibit the growth of tubercle bacillus and arrest tuberculosis. 

Flfluro 4 Mechanism of action of l-upsnigiiiUE (1-ASP). The growth of l-asparagine-dependent turnon is inhibited if this essential substrate Is hydrolyzed to ammonia and 1-aspartate. 

Asparaginase - L-asparagine amidohydrolase (E.C. 3.5. 1. 1) inhibits growth of some murine lymphomas and leukemias it is presently undergoing preliminary clinical trial. In leukemic patients, a drug-associated... 

This enzyme depletes cells of asparagine, an amino acid crucial to the manufacture of cellular proteins used in growth and metabolism. This depletion results in inhibition of protein synthesis and cell death. 

The stimulation of amino acid uptake is oxygen dependent but is not inhibited by cyanide and dinitro-phenol. The effect of growth hormone on a-aminoiso-butyric acid has been extended to a number of natural amino acids, and it has been established that growth hormone stimulates the uptake of glycine, alanine, serine, proline, threonine, histidine, tryptophan, glutamine, and asparagine, but is without effect on the uptake of dicarboxylic acids, ethionine, valine, tyrosine, phenylalanine, leucine, lysine, and arginine. 

Synthesis of Pantothenate. Inhibition of the growth of yeasts from 8-alanine by aspartic acid (89,90) and by asparagine (101,120) has been ascribed to inhibition of the synthe.sis of pantothenic acid from /3-alanine. In the latter instance inhibition with several strains could be prevented by higher concentrations of /3-alanine or by replacing 8-alanine by pantothenic acid (101). Inhibition of growth of yeasts from /3-alanine was cau.sed also by 8-aminobutyric acid, and a similar explanation has been given (38,88). Systems concerned in the synthesis have been studied (124). 

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