T cell depletion

Small, T.N. et al., Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation effect of patient age and donor leukocyte infusions,... 

Desvignes C, Bout H, Nicolas J-F, Kaiserlian D Lack of oral tolerance but oral priming for contact sensitivity to dinitrofluorobenzene in major histocompatibility complex class Il-defident mice and in CD4+ T-cell-depleted mice. Eur J Immunol 1996 26 1756-1761. 

Gajewski J, GJertson D, Cecka M et al. The impact of T cell depletion on the effects of HLA-DRBl and DQB allele matching in HLA serologically identical unrelated donor bone marrow transplantation. Biol. Blood Marrow Transplant 1997 3 76-82... 

Lee, S.T., Jang, J. H., Cheong, J. W., et al. (2002),Treatment of high-risk acute myelogenous leukaemia by myeloablative chemoradiotherapy followed by co-infusion of T cell-depleted haematopoietic stem cells and culture-expanded marrow mesenchymal stem cells from a related donor with one fully mismatched human leucocyte antigen haplotype, Br. J. Haematol, 118(4), 1128-1131. 

The use of HLA-non-identical T-cell-depleted marrow transplants for correction of severe combined immunodeficiency disease. O Reilly, R.J., Keever, C.A., Small, T.N., Brochstein, J. (1989). Immunodefic Rev, 1 (4) 273-309. 

Although this chapter will only discuss IMS in relation to cell-sorting, this approach has also been adapted for DNA sequencing (1), purification of DNA binding proteins (2), immobilization and isolation of nucleic acids (3), tissuetyping (4,5), quantification of lymphocyte subsets directly from blood (6), bone marrow T-cell depletion (7), depletion of malignant neuroblastoma cells from... 

Kleine, H. D., Schienichen, Lux, E., Pohwoda, H, and Freund, M. (1993) A constant flux system using magnetic cell separator (MACS) for highly efficient T-cell depletion Anal Cell Pathol 5,125—128... 

Bunin N, Aplenc R, Leahey A, Magira E, Grupp S, Pierson G, Monos D. Outcomes of transplantation with partial T-cell depletion of matched or mismatched unrelated or partially matched related donor bone marrow in children and adolescents with leukemias. Bone Marrow Transplant 2005 35 151-8. 

Hsu D, Shi JD, Homola M, Rowell TJ, Moran J, Levitt D, Druilet B, Chinn J, Bullock C, Klingbeil C. A humanized anti-CD3 antibody, HuM291, with low mitogenic activity, mediates complete and reversible T-cell depletion in chimpanzees. Transplantation 1999 68 545-54. 

Regulatory (suppressor) T-cells. These maintain tolerance. Cells which can transfer tolerance are CD4+ and CD25+ T-cells. Depletion of cells, with this phenotype, from normal mice or from normal cells given to athymic mice, results in the development of autoimmune disease. This tolerance is dominant. 

Lytletton, M. P. A., Browett, P. J., Bremner, M. K., Cordingley, F. T., Kohlman, J, McGee, J. O D., Hamilton-Dutoit, S, Premice, M. G., Hoffbrand, A. V. (1988) Prolonged remission of Epstein-Barr virus associated lymphoma secondary to T cell depleted bone marrow transplantation. Bone Marrow Transplantation%, 641-646. 

Brenner MK, Wimperis JZ, Reittie JE, Patterson J, Asherson GL, Hoffbrand AV, Prentice HG. Recovery of immunoglobulin isotypes following T cell depleted allogeneic bone marrow transplantation. Br J Haematol 1986 64(l) 125-32. 

HIV is a human retrovirus that infects lymphocytes and other cells with the CD4 surface protein. Infection eventually leads to lymphopenia and CD4 T-cell depletion. The time from onset of HIV infection to development of AIDS varies from months to years. 

Discrepancies between the effects of 008" T cell depletion on the early and later stages of the immune response are not uncommon. In the mercuric chloride-induced model of autoimmune disease (Mathieson et al., 1991),... 

Holmes, B.J., Diaz-Sanchez, D., Lawrence, R.A., Maizels, R.M. and Kemeny, D.M. (1994). The effect ofCDS T cell depletion on the primary and established IgE response. FASEB J. 8, A763. 

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