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Arthritis, gouty, drugs used

Phenylbutazone and sulfinpyrazone can hydrolyze to yield 1,2-diphenylhydrazine and these drugs may contain some 1,2-diphenylhydrazine (Ahuja et al. 1988 Fabre et al. 1984 Matsui et al. 1983). Phenylbutazone is a drug used for the treatment of inflammatory conditions (e.g., arthritis) and sulfinpyrazone is used to treat gouty arthritis. Although potential exists for exposure to 1,2-diphenylhydrazine via from treatment. with these drugs, no information regarding body burden was located in the literature... [Pg.54]

Drugs used in the management of gout are To treat acute gouty arthritis... [Pg.311]

Certain drugs bind to microtubules and thus interfere with their assembly or disassembly. These include colchicine (used for treatment of acute gouty arthritis), vinblastine (a vinca alkaloid used for treating certain types of cancer), paclitaxel (Taxol) (effective against ovarian cancer), and griseoflilvin (an antifungal agent). [Pg.577]

As was already mentioned, piroxicam also is a nonsteroidal, anti-inflammatory drug. It is used in inflammatory and degenerative diseases of the musculoskeletal system that are accompanied by painful symptoms. It is used for rheumatic heart disease, nonspecific infectious polyarthritis, gouty arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, arthrosis, back pain, nenralgia, myalgia, and other diseases associated with inflammation. Synonyms for piroxicam are feldene, dexicam, roxenan, and others. [Pg.52]

Acute gouty arthritis-50 mg 3 times/day until pain is tolerable, then rapidly reduce the dose to complete cessation of the drug. Definite relief of pain usually occurs within 2 to 4 hours. Tenderness and heat usually subside in 24 to 36 hours, and swelling gradually disappears in 3 to 5 days. Do not use sustained-release form. [Pg.928]

Allopurinol is an xanthine oxidase inhibitor. It reduces urate production and is used in primary and secondary urate overproduction. Therapy of hyperuricemia prevents recurring attacks of acute gouty arthritis. Allopurinol dosages are 300 mg/day for serum creatinine < 1.5 mg/dl and 100 mg/day for serum creatinine between 1.6-2.0 mg/dl. Reduction of tophi is slow with allopurinol, particularly in patients with giant tophi and renal insufficiency where drug dosage is limited. [Pg.670]

The prototypes of this large class of NSAIDs are in-domethacin and ibuprofen. These drugs are indicated for the relief of acute and chronic rheumatoid arthritis and osteoarthritis. In addition, a number of drugs of this class are also useful in ankylosing spondylitis, acute gouty arthritis, bursitis, and tendinitis. [Pg.429]

A number of drugs other than those discussed in detail in this chapter have been used to control the symptoms of acute gouty arthritis. Since the principal aspects of their pharmacology have been described elsewhere, they are mentioned only briefly here. [Pg.446]

Phenylbutazone (Butazolidin, Tandearil) (see Chapter 36) also displays antipyretic, analgesic, and antiinflammatory activity. In addition, it possesses some uricosuric potency and therefore is widely used for the treatment of acute attacks of gouty arthritis, in which it is about equal to colchicine in effectiveness. Although the drug does promote the renal excretion of uric acid, its usefulness is generally attributed to its antiinflammatory actions. [Pg.446]

Hepatotoxicity is the major concern in 15% of pyrazinamide recipients. It also can inhibit excretion of urates, resulting in hyperuricemia. Nearly all patients taking pyrazinamide develop hyperuricemia and possibly acute gouty arthritis. Other adverse effects include nausea, vomiting, anorexia, drug fever, and malaise. Pyrazinamide is not recommended for use during pregnancy. [Pg.560]

The major toxicity associated with ethambutol use is retrobulbar neuritis impairing visual acuity and red-green color discrimination this side effect is dose related and reverses slowly once the drug is discontinued. Mild GI intolerance, allergic reaction, fever, dizziness, and mental confusion are also possible. Hyperuricemia is associated with ethambutol use due to a decreased renal excretion of urates gouty arthritis may result. [Pg.560]

Long-term hypouricaemic agents that decrease serum uric levels should not be used during an acute attack. This is because these drugs cause the mobilisation of uric acid stores in response to a decreasing serum level. This can then prolong the attack or precipitate another attack of gouty arthritis. [Pg.264]

The major side effects associated with uricosuric therapy are gastrointestinal irritation, rash and hypersensitivity, precipitation of acute gouty arthritis, and stone formation. These drugs are contraindicated in patients who are allergic to them and in patients with impaired renal function (a creatinine clearance <50 mL/min), a history of renal calculi, and in patients who are overproducers of uric acid for such patients, allopurinol should be used. [Pg.1709]

Three treatments are available for patients with acute gouty arthritis. Colchicine is less favored now than in the past because its onset of action is slow and it invariably causes diarrhea. Nonsteroidal antiinflammatory drugs, which are currently favored, are rapidly effective but may have serious side effects. Corticosteroids, administered either intraarticularly or parenterally, are used increasingly in patients with monarticular gout, especially if oral drug therapy is not feasible. [Pg.311]

Pharmacokinetics and clinical use Chronic gout is treated orally with a uricosuric or allopurinol. These drugs are of no value in acute gouty arthritis and are best withheld for 1-2 weeks after an acute episode. [Pg.327]

Croom KF, Siddiqui MA. Etoricoxib a review of its use in the symptomatic treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and acute gouty arthritis. Drugs 2009 69(11) 1513-1532. [Pg.244]

Synthesis of Sulindac Sulindac 23 is a nonsteroidal anti-inflammatory drug mainly used in the treatment of pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gouty arthritis. More recently, it attracted also the attention of the scientists for its anticancer effects. It used to be sold in its racemic form, but its enantiopure preparation was known since 2001. The... [Pg.1477]


See other pages where Arthritis, gouty, drugs used is mentioned: [Pg.840]    [Pg.136]    [Pg.139]    [Pg.48]    [Pg.353]    [Pg.426]    [Pg.443]    [Pg.446]    [Pg.447]    [Pg.816]    [Pg.817]    [Pg.136]    [Pg.139]    [Pg.164]    [Pg.483]    [Pg.457]    [Pg.1501]    [Pg.222]    [Pg.463]    [Pg.474]    [Pg.207]   
See also in sourсe #XX -- [ Pg.326 , Pg.326 , Pg.327 ]




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