Arthritis drugs

Schlesinger N. Management of acute and chronic gouty arthritis. Drugs 2004 64 2399-2416. 

Antibiotics Isoniazid Penicillins Hypersensitivity and Autoimmunity Rash, dermatitis, vasculitis, arthritis, drug-induced SLE Anaphylaxis, dermatitis vasculitis, serum sickness, hemolytic anemia... 

Figure 1.6 The structures of (a) the MRI contrast agent Gd-DTPA and (b) the orally active anti-rheumatoid arthritis drug Auranofin .

Petersen, M., Pushing pills with piles of money Merck and Pharmacia in arthritis drug battle. 

Culy CR, Keating GM. Etanercept. An updated review of its use in rheumatoid arthritis, psoriatic arthritis and juvenile rheumatoid arthritis. Drugs 2002 62 2493-537. 

KUnkhoff A. Biological agents for rheumatoid arthritis. Drugs 2004 64 1267-83. 

Debashis S. Merck withdraws arthritis drug worldwide. Brit Med J 2004 329 816... 

Langevitz P, Livneh A, Bank I, Pras M. Benefits and risks of minocycline in rheumatoid arthritis. Drug Saf 2000 22(5) 405-14. 

Siddiqui MA, Scott LJ. Infliximab a review of its use in Crohn s disease and rheumatoid arthritis. Drugs 2005 65(15) 2179-208. 

Plosker G, Croom K Sulfasalazine A review of its use in the management of rheumatoid arthritis. Drugs 2006 65 1825. 

B. M. Sutton, Overview and Current Status of Gold-Containing Anti-Arthritis Drugs , in ref. 6, pp, 355—366. 

Camussi G, Lupia E (1998) The future role of anti-tumor necrosis factor (TNF) products in the treatment of rheumatoid arthritis. Drugs 55(5) 613—620... 

Anonymous, Modifying disease in rheumatoid arthritis. Drug Ther. Bull. 36 3-6, 1998. 

For example, soon after the new arthritis drug Celebrex entered the market, the FDA received 53 reports of dispensing errors that occurred when it was mistaken for the antiseizure drug Cerebyx or the antidepressant drug Celexa. Other commonly... 

Monsanto also uses a similar process to produce a single enantiomer of the arthritis drug Naproxen, a nonsteroidal anti-inflammatory drug (NSAID). Note that this asymmetrical hydrogenation produces only the (.S )-cnantiomer of the drug in a yield of 98.5% from an achiral precursor ... 

Muller-Ladner U, Gay S. The SCID mouse—a novel experimental model for gene therapy in human rheumatoid arthritis. Drugs Today (Barcelona) 1999 35 379-88. 

Because tetrazoles have similar acidities to those of carboxylic acids, they have been used in drugs as replacements for the CO2H unit when the carboxylic acid has unsatisfactory properties for human medicine. A simple example is the anti-arthritis drug indomethacin whose carboxylic acid group maybe replaced by a tetrazole with no loss of activity. 

More useful sulfur compounds have included the leprosy drug dapsone (Chapter 6), the arthritis drug Feldene... 

B. Caterson. Fishing for arthritis drugs. Chemistry in Britain, April 2000, 20 (summary of Journal of Biological Chemistry, 2000, 275, 721). 

Worse news—though the retired Merck scientists and secretaries in the purple auditorium don t know it—is yet to come. Within the next three months, there will be regulatory questions about their company s hot new arthritis drug and accounting questions about its Medco subsidiary, and their stock s value will plummet. 

Merck s blockbuster arthritis drug Vioxx, in fact, got its start at a lecture, according to a story in the Asian Wall Street Journal in January 2001. At a medical conference in Montreal in 1992, Peppi Prasit, then a medicinal chemist at Merck, noticed a display from a Japanese company about a painkiller that supposedly didn t upset the stomach but that, unfortunately, wasn t chemically appropriate for people. Prasit knew that Merck was looking for a painkiller without stomach problems. So he went back to his lab and started to concoct it. 

A thirty-second spot for cereal is just a commercial. Other than the occasional complaint that it encourages children to eat sugared foods or demand some tie-in toy, there s not much dispute about commercials for cereals. An ad for an allergy or arthritis drug, on the other hand, is a window into medical ethics, the role of government, the cost of health care, self-medication, and the doctor-patient relationship. 

Merck is to spend 675 million on legal fees to defend itself against writs from patients who suffered side-effects from the arthritis drug Vioxx. Pfizer defends and continues promoting Celebrex (its own Vioxx) for current use and for potential new uses in cancer trials. ... 

Kolata G. A widely used arthritis drug is withdrawn. The New York Times, October 1, 2004. (Internet at http //www.nytimes.com.)... 

Mikuls TR, Moreland LW. Benefit-risk assessment of infliximab in the treatment of rheumatoid arthritis. Drug Saf 2003 26(l) 23-32. 

McCurry J. Japan deaths spark concerns over arthritis drug. Lancet 2004 363(9407) 461. 

Moynihan R. FDA officials argue over safety of new arthritis drug. BMJ 2003 326(7389) 565. 

Cassidy JT. Medical management of children with juvenile rheumatoid arthritis. Drugs 1999 58(5) 831-50. 

Pfizer abandoned tenidap sodium for use in rheumatoid arthritis after a non-approval letter from the FDA was issued because of unresolved questions about its safety. The decision related only to the 120 mg dose. The FDA s Arthritis Drugs Advisory Committee also voted against approving tenidap sodium for osteoarthritis. 

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