Arsenic intoxication

Prolonged dosages of 3-4 mg daily produced clinical symptoms of chronic arsenic intoxication Prolonged use produced symptoms of chronic arsenic intoxication (0.6 mg/L) or skin cancer (0.29 mg/L)... 

Mathews, N.E. and W.F. Porter. 1989. Acute arsenic intoxication of a free-ranging white-tailed deer in New York. Jour. Wildl. Dis. 25 132-135. 

Stine, E.R., C.A. Hsu, T.D. Hoovers, H.V. Aposhian, and D.E. Carter. 1984. N-(2,3-dimercaptopropyl) phthal-amidic acid protection, in vivo and in vitro, against arsenic intoxication. Toxicol. Appl. Pharmacol. 75 329-336. 

Toxicology. Lead arsenate may cause lead and/or arsenic intoxication arsenic symptoms likely predominate in acute intoxication, whereas prolonged inhalation of lead arsenate may induce the symptoms of lead intoxication. ... 

Some of the effects of acute arsenic intoxication are nausea, vomiting, diarrhea, and irritation inflammation and ulceration of the mucous membranes and skin and kidney damage. Among the effects of chronic arsenic poisoning are increased pigmentation and keratinization of the skin, dermatitis, and epidermoid carcinoma. Other effects seen after ingestion, but which are not common from industrial exposure, are muscular paralysis, visual dismrbances, and liver and kidney damage. ... 

SYMPTOMS - Painful vomiting and diarrhea, after a delay of up to an hour or so, eventual collapse of the central nervous system. Ingestion of a large quantity of arsenic, which is rapidly absorbed, and especially if alcohol is also consumed, produces paralytic poisoning the most dangerous form of arsenic intoxication. This causes depression of the CNS and quick death. Caution should be used as large doses may cause vomiting before it can be absorbed. 

Huet, P.M., Guillaume, E. and Cote, J. (1975) Noncirrhotic presinusoidal portal hypertension associated with chronic arsenical intoxication. Gastroenterology, 68(5), 1270-77. 

Lugo, G., Cassady, G. and Palmisano, P. (1969) Acute maternal arsenic intoxication with neonatal death. American Journal of Diseases of Children, 117(3), 328-30. 

Arsenic Arsenic poisoning is of great medicohistorical interest, (s. p. 564) Chronic arsenic intoxication can be caused by inhalation or, more often, by oral uptake. Steatosis and cell necrosis occur in the liver fibrosis or cirrhosis with portal hypertension and oesophageal varices develop. The presence of liver adenoma and VOD as well as hver carcinoma or haemangioendothelioma has been described. (16, 42, 50, 53, 60, 76)... 

Adverse findings still could not be avoided and had to be downplayed. Buried 57 pages into the report text is the information that Diagnoses of low-grade lead arsenate intoxication were made on seven workers the summary at the front of the document distorts this into... 

Some physicians may interpret these cases as minimal lead arsenate intoxication. However, as regards lead, these cases do not come up to the criteria.., 12... 

Heyman A, Pfeiffer JB, Willett RW, et al Peripheral neuropathy caused by arsenical intoxication. N Engl J Med 254 401-409, 1956 Jenkins RB Inorganic arsenic and the nervous system. Brain 89 479-498,1966 Krainer L, Black DAK, McGill RJ, et al Arsenical encephalopathy in Indian troops. 

Fig. 3.4 Electron-dense material in the mitochondrial cytoplasm (cardiac muscle) following arsenic intoxication. (Original magnification, x43 650.)...

Franzbiau, A., Lilis, R. (1989). Acute arsenic intoxication from environmenmtal arsenic exposure. Arch. Environ. Health 44, 385-390. 

Chronic arsenic poisoning Chronic arsenic intoxication is manifested by skin changes, hair loss, bone marrow depression and anemia, and chronic nausea and gastrointestinal disturbances. Dimercaprol therapy appears to be of value. Arsenic is a known human carcinogen. 

B. Specific drugs and antidotes. Treat seriously symptomatic patients with chelating agents, which have shown therapeutic benefit in animal models of acute arsenic intoxication when administered promptly (ie, minutes to hours) after exposure. Treatment should not be delayed during the several days often required to obtain specific laboratory confinnation. 

Acute and chronic arsenic intoxications, excepting suicides or accidents, have become rare in Western countries. Air controlling of all dangerous parts in factories and regular medical surveillance of workers has reduced the risk of chronic arsenic poisoning to near zero. Pesticides, especially ant killers taken by children, were the predominant cause of As intoxication in the USA in recent years [12,37-39,49,50]. 

How-Ran Guo (epidemiology environmental health and medicine health impacts of water contaminants cancers and chronic diseases in endemic areas of arsenic intoxication epidemiologic characteristics of diseases associated with arsenic). Department of Environmental and Occupational Health, College of Medicine, National Cheng-Kung University (NCKU), Tainan... 

Clouded urine is frequently seen in most severely arsenic-intoxicated patients as absorbed arsenic if primarily excreted through urine (Hughes and Kitchin, 2006). Increased urinary protein content and aberrant... 

Goebel, H.H., Schmidt, RE, Bohl, J., et al., 1990. Polyneuropathy due to acute arsenic intoxication biopsy studies. J. Neuropathol. Exp. Neurol. 49,137-149. 

Rezuke, W.N., Anderson, C., Pastuszak, W.T., et al., 1991. Arsenic Intoxication Presenting as a Myelodysplastic Syndrome A Case Report. Am. J. Hematol. 

Shila, S., Kokilavani, V, Subathra, M., et al, 2005. Brain regional responses in antioxidant system to alpha-lipoic acid in arsenic intoxicated rat. Toxicology 210, 25-36. 

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