Carcinogens aromatic

Klibenzanthracene, C22H 4. Crystallizes in silvery leaflets, m.p. 262 C. A polycyclic aromatic carcinogen obtained from coal tar. The 7,8 derivative, m.p. 196, is also known. 

Proteins, Solid, Adsorption of Water on (Eley Leslie). Proteins and Nucleic Acids, Electronic Structure Proteins and Nucleic Acids, Influence of Physical Agents on Purine-Pyrimidine Pairs, Steroids, and Polycyclic Aromatic Carcinogens (Pullman). ... 

Steroids, Purine-Pyrimidine Pairs, and Polycyclic Aromatic Carcinogens (Pullman). ... 

STEROIDS, PURINE-PYRIMIDINE PAIRS AND POLYCYCLIC AROMATIC CARCINOGENS ... 

Energy Refined Polymer Models of DNA Modified by Polycyclic Aromatic Carcinogens. ... 

Fieser, Louis F. (1899-1977). A distinguished American chemist, Fieser became professor of organic chemistry at Harvard in 1930 after teaching for several years at Bryn Mawr. He achieved the synthesis of vitamin and did fundamental research on cortisone, the chemistry of steroids, and aromatic carcinogens. His achievements as a chemist and educator are recognized throughout the world. Unique in his facility in laboratory demonstration and as a lecturer and author, he exemplified... 

Chlorophyllin Green vegetables Aromatic carcinogen sequestering... 

Gupta, R. C., Reddy, M. V., and Randerath, K. (1982). 32P-postlabeling analysis of nonradioactive aromatic carcinogen-DNA adducts. Carcinogenesis 3, 1081-1092. 

The population balance between these differing conformations is governed by the specific nature of the aromatic carcinogen as well as the neighboring base sequence contexts. A predominant (90-95%) B-conformer has been experimen-... 

Geadntov, N.E., Cosman, M., Hingerty, B.E., Amin, S., Broyde, S., and Patel, D.J. (1997) NMR solution structures of stereoisometric covalent polycyclic aromatic carcinogen-DNA adduct principles, patterns, and diversity. Chem. Res. Toxicol., 10, 111-146. 

Xu, R. (1994) Studies of characteristics of DNA-polynudear aromatic carcinogen adducts at atomic and molecular resolution levels. PhD Thesis. New York University, New York. 

D. J. (1997) NMR solution structures of stereoisomeric polycyclic aromatic carcinogen-DNA adducts principles, patterns and diversity. Chem. Res. Toxicol, 10,111-146. 

Malignant transformation by chemical agents are believed to be the earliest steps which involve covalent binding of the substances to cellular DNA. Fish taken as samples from PAH-contaminated areas of the Buffalo and Detroit rivers have been shown to have elevated liver cancer rates and have demonstrably higher levels of aromatic carcinogens — DNA adducts [23]. 

Van Duuren, B.L. Separation and identification of aliphatic and aromatic carcinogens from environmental sources Natl. Cancer Inst. Monograph 9 (1962) 135. 

An approximate order of response for the halogens is F < Cl < Br < I. Applications include trace analysis of environmental samples for chlorinated solvents, plasticisers, chlorofluorocarbon gases, pesticides and herbicides (DDT, 7BHC/lindane, aldrin), SFg tracer gas in flue gases and mine atmospheres, organometallics (lead tetra-alkyls), polynuclear aromatic carcinogens, NO and SO2 in chimney-stack gases. 

Dipple, Anthony. Polynuclear Aromatic Carcinogens. "Chemical Carcinogens." Charles E. Searle, Ed. ACS Monograph 173 1976, American Chemical Society, Washington, DC. 

Free radicals are generated in many pyrolysed or charred food-stuffs, although their effect in vivo (in the digestive tract) is unknown [123]. Radical cations of aromatic carcinogens, prepared and trapped both from oxidation [124] and from complexes with tetrachloro-o-benzoquinone [125, 126], led to the suggestion that free radicals from complexes in vivo are carcinogenic initiators. Evidence of free radicals in such systems is well-documented although not... 

Investigation of the target-area side of the problem, i.e. the growth mechanism or metabolic function disrupted by aromatic carcinogens, may lead to the... 

In an innovation, Newman applied polyphosphoric acid (PPA) in place of the usual mixture of hydrobromic acid and acetic acid. PPA had been used earlier in the aromatic cyclodehydration for preparation of phenanthrene derivatives. Newman applied PPA under thermal conditions for the aromatic cyclodehydration of an unactivated ketone 16 to afford 17, an aromatic carcinogen, in moderate yield. In contrast, the use of a mixture of hydrobromic and acetic acids failed to give the cyclized product. 

Guill6n M.D., Sopelana P., Partearroyo MA. Food as a source of polycyclic aromatic carcinogens. Reviews on Environmental Health, 12 ... 

TMSCF3 has been used in the preparation of polycyclic aromatic carcinogens, the key step being the addition of TMSCF3 to the carbonyl group (eq 4) ... 

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