Carcinogens aromatic amines

Sellakumar AR, Montesano R, Saffiotti U. 1969. Aromatic amines carcinogenicity in hamsters. Division of Oncology. The Chicago Medical School and Eppley Inst, for Res in Cancer, University of Nebraska, Omaha, [abstract]... 

Sellakumar AR, Montesano R, Saffiotti U Aromatic amines carcinogenicity in hamsters. Proc Am Assoc Cancer Res 10 78, 1969. 

Brennan, R.J and R.H. Schiestl. 1999. The aromatic amine carcinogens o-toluidine and o-anisidine induce free radicals and intrachromo-somal recombination in Saccharomyces Cere-visiae Mutat. Res. 430 37-45. 

Knize, M. G., Salmon, C. R, Mehta, S. S., and Felton, J. S. 1997b. Analysis of cooked muscle foods for heterocyclic aromatic amine carcinogens. Mutat. Res. 376 129-134. 

Eight heterocyclic aromatic amine carcinogens were extracted from cooked meats. A Cjg column and a complex 30-min 95/5- 45/55 water (lOmM triethylamine phosphate at pH 3.6)/acetonitrile resolved 2-amino-1-methyl-, 2-amino-3,8-dimethyl-, and 2-amino-3,4,8-trimethylimidazo[4,5-/]quinoxaline with monitoring by UV (A = 262 nm) and fluorescence (A = 307 nm, ex 370 nm, em). A 40-min 95/5—>-20/80 water (25 mM triethylamine phosphate at pH 3.6)/acetonitriIe gradient on the same column resolved 2-amino-1,6-dimethylimi-... 

B. N. Ames, E. G. Gurney, J. A. Miller, and H. Bartsch, Carcinogens as frameshift mutagens Metabolites and derivatives of 2-acetylaminofluorene and other aromatic amine carcinogens, Proc. Natl. Acad. Sci. U.S.A. 69, 3128-3132 (1972). 

UK Ministry of Agriculture Fisheries and Food and Flealth and Safety Executive, Annual Report of the Working Party on Pesticide Residues in Food (1997), MAFF Publications, London, 1997. lARC, Monographs on the Evabiation of the Carcinogenic Risk of Chemicals to Hnmans Volume 56 Some Naturally Occurring Substances Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins, WFIO, Geneva, 1979, p. 397. 

CYP1B1 (chromosome 5) has been linked to primary congenital glaucoma. CYP1B1 is not regularly expressed in liver but is often found in various kinds of tumours. It metabolizes retinoids and many aromatic amines and PAHs to potentially carcinogenic products. 

One of the main concerns regarding azo dyes is related to the possibility of their reduction by azoreductases, with the formation of unsulfonated aromatic amines with potential carcinogenicity. 

Fouarge M, Mercier M, Poncelet F (1984) Liver, kidney and small-intestine microsomal-mediated mutagenicity of carcinogenic aromatic amines. Mutat Res 125(1) 23-31... 

The carcinogenicity of aromatic amines, such as benzidine and 2-naph-thylamine, was first recognized by Rehn in the 1890s as an occupational hazard in the German dyestuffs industry. Compounds in this class induce... 

Hildenbrand S, Schmahl FW, Wodarz R et al (1999) Azo dyes and carcinogenic aromatic amines in cell culture. Int Arch Occup Environ Health 72 M52... 

From appraisal of their respective resonance stabilisation, arylnitrenium ions and alkoxynitrenium ions should form with similar facility. On account of the fact that A-acetoxy-A-acetyl arylamines 7 are penultimate carcinogens in the metabolism of aromatic amines, A-acyloxy-A-alkoxyamides 3 were designed to test their potential as DNA-damaging agents. 

Carcinogenic compounds, 9 448 aromatic amine, 9 450 in dye production, 9 296 Carcinogenic elements, in ferrites, 11 59 Carcinogenicity. See also Cancer of acetaldehyde, 25 561 classification scheme for, 13 311 of herbicides, 13 311 hydrazine, 13 590-591 methanol, 16 314 of propylene oxide, 20 811 testing, 25 221-223 of 2,4-D, 13 315 Carcinogenic potential, 25 222 Carcinogenic risk, of nickel compounds, 17 120... 

The enzyme can also catalyze the transfer of an acetyl group from an N-acetylated hydroxylamine (hydroxamic acid) to form an acetoxy product, i.e., an N to O transacetylation and this pathway does not require acetyl Co-A (12). A-hydroxy-4-acetylaminobiphenyl provides an example of this conversion as shown in Figure 7.7. The significance of this pathway is that it leads to the activation of the hydroxamic acid because acetoxy derivatives of aromatic amines are chemically reactive and many are carcinogens such as the heterocyclic amines formed when meat is heated to a high temperature, e.g., 2-amino-1-mcthyl-6-phenylirnidaz()[4,5-i ]pyri(linc. 

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