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Carcinogenicity initiation

Tumour type Species/strain (sex) Known carcinogen (initiator) Route of administration Interval between initiator and promoter Dose and duration of DEHP Route of administration Promoting activity for DEHP Reference... [Pg.65]

How these "specific binding sites" for metabolites in the DNA are related to mutagenesis, cancer, or toxicity, however, remains to be determined. One recent hypothesis1 8 489 is that covalently bound reactive metabolites cause the movement of transposable elements to new locations in genomic DNA and that this process represents carcinogenic "initiation."... [Pg.59]

McKee, R.H., R.T.Plutnick,and R.T. Przygoda. 1989. The carcinogenic initiating and promoting properties of a lightly refined paraffinic oil. Fundam. Appl. Toxicol. 12 748-756. [Pg.139]

Ail mice wre carcinogenically initiated with DMBA (390 nmol) and promoted with TPA (1.7 nmol) given twice weekly starting 1 week after initiation. [Pg.227]

Free radicals are generated in many pyrolysed or charred food-stuffs, although their effect in vivo (in the digestive tract) is unknown [123]. Radical cations of aromatic carcinogens, prepared and trapped both from oxidation [124] and from complexes with tetrachloro-o-benzoquinone [125, 126], led to the suggestion that free radicals from complexes in vivo are carcinogenic initiators. Evidence of free radicals in such systems is well-documented although not... [Pg.181]

See other pages where Carcinogenicity initiation is mentioned: [Pg.318]    [Pg.98]    [Pg.1319]    [Pg.157]    [Pg.77]    [Pg.1319]    [Pg.115]    [Pg.279]    [Pg.148]    [Pg.296]    [Pg.34]    [Pg.44]    [Pg.1217]    [Pg.238]    [Pg.258]    [Pg.266]    [Pg.267]    [Pg.448]    [Pg.154]    [Pg.85]    [Pg.794]    [Pg.398]    [Pg.643]    [Pg.174]    [Pg.1213]    [Pg.132]    [Pg.32]    [Pg.158]    [Pg.198]    [Pg.199]    [Pg.201]    [Pg.450]   


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