Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Radiation-induced apoptosis

One vitamin E analogue, TROLOX, inhibits radiation-induced apoptosis in murine thymocytes (26). Chicks given vitamin E prior to exposure to a sublethal dose (2.25 Gy (225 rad)) of y-radiation demonstrate a more rapid recovery from damage to the thymus (100). [Pg.491]

Barber, L. A. et al., Expression of the platelet-activating factor receptor results in enhanced ultraviolet B radiation-induced apoptosis in a human epidermal cell line, J. Biol. Chem. 273, 18891-18897, 1998. [Pg.273]

Schwarz, A. et al., Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair, Nat. Cell. Biol. 4,26-31, 2002. [Pg.274]

Bohm, M. et al., Alpha-melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage, J. Biol. Chem. 280, 5795-5802, 2005. [Pg.275]

Tomei, L.D. et al., Psychological stress and phorbol ester inhibition of radiation-induced apoptosis in human peripheral blood leukocytes, Psychiat. Res., 33, 59, 1990. [Pg.524]

The sensitivity to ionizing radiation is maximal in those cells able to activate a co-ordinate program of cell death (apoptosis) primed by the radiation-induced oxidative stress. Albeit apoptosis is a nuclear event and radiation-induced DNA damage is probably the most relevant mechanism of initiation of apoptosis, the control of the execution phase (and sometime also the initiation) takes place at the mitochondrial level. Radioresistance occurs... [Pg.171]

Several genetic alterations can influence radiosensitivity of cancer cells and radioresponsive tumors are known to allow more easily radiation-induced apoptosis. Therefore, the proper functioning of the apoptotic machinery regulates radiosensitivity. As described above, a cracial role is played by p53, and its downstream genes p21 and bax, in activating the apoptotic process. Those cancers with mutations at these levels are expected to be radioresistant. [Pg.182]

Santana, P, Pena, L.A, Haimovitz-Friedman, A, Martin, S., Green, D., McLougWin, M., Cordon-Cardo, C., Schuchman, E.H., Fuks, Z. and Kolesnick, R., 1996, Acid sphingomyehnase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 86 189-199... [Pg.243]

SU-6656 (12) [113-115] is a potent inhibitor of Src kinase (as well as Lck, Fyn, and Yes kinases) and is an effective inhibitor of PDGF-stimulated DNA synthesis and Myc induction in a fibroblast cell line. SU-6656 has also been a useful tool for investigating the role of Src and Ras-ERK signal transduction in Src-transformed cells with respect to Racl, as well as implicating Vav2 and Tiaml as downstream effectors of Src to modulate Racl-dependent pathways. In endothelial cells, SU-6656 is effective in increasing radiation-induced apoptosis and vascular endothelium destruction, and in vivo studies have... [Pg.396]

Staurosporine, UCN-01, and UCN-02 (a weak PKC inhibitor) induced a concentration- and time-dependent increase in apoptosis, whereas neither CGP 41251, RO 31-8220, nor GF 109203X induced apoptosis in immature rat thymocytes. In the human cell line BM13674 the specific inhibition of PKA gave rise to significantly increased levels of apoptosis at postirradiation compared to values after radiation e3q>osure only. Calphostin C which caused 68% inhibition of PKC activity in irradiated cells, did not alter the level of radiation-induced apoptosis (Findik et al., 1995). [Pg.36]

Ferry DR, Smith A, Malkhandi J, F e DW, deTakats PG, Anderson D, Baker J, Kerr DJ (1996) Phase 1 clinical trial of the flavonoid quercetin pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin Cancer Res 2 659-668 Findik D, Song Q, Hidaka H, Lavin M (1995) Protein kinase A inhibitors enhance radiation-induced apoptosis. J Cell Biochem 57 12-21 Fine RL, Patel J, Chabner BA (1988) Phorbol esters induce multidrug resistance in human breast cancer cells. Proc Natl Acad Sci USA, 85 582-586 Finkenzeller G, Marme D, Hug H (1992) Inducible overexpression of human protein kinase C in NIH 3T3 fibroblasts results in growth abnormalities. Cell Signall 4 163-177... [Pg.70]

Kelly ML, Tang Y, Rosensweig N, Clejan S, Beckman BS (1998) Granulocyte-macrophage colony-stimulating factor rescues TF-1 leukemia cells from ionizing radiation-induced apoptosis through a pathway mediated by protein kinase Ca. Blood 92 416-424... [Pg.77]

Of course other methods of radiation enhancement may take place with reoxygenation of hypoxic tumor cells that may be increased with the use of chemotherapies like paclitaxel or gemcitabine (41,42), improved drug access to the tumor cells after radiotherapy, or a lowering of the threshold for radiation-induced apoptosis as has been described with the use of gemcitabine (43). [Pg.10]

FuksZ. Intravenous bFGF protects the lung against radiation-induced apoptosis in vivo. Cancer J1995 1 62-72. [Pg.375]

Injury to cell plasma membrane can activate acid sphingomyelinase to break down membrane lipid sphingomyelin and generate the second messenger ceramide, a complex lipid, to initiate the apoptosis (HI). Ceramide, perhaps through intracellular mitogen-activated protein kinases (MAPK), can alter cellular susceptibility to TNF-a, FasL, and ionizing radiation-induced apoptosis (HI, Wll). [Pg.68]


See other pages where Radiation-induced apoptosis is mentioned: [Pg.488]    [Pg.494]    [Pg.495]    [Pg.69]    [Pg.69]    [Pg.71]    [Pg.518]    [Pg.172]    [Pg.175]    [Pg.177]    [Pg.179]    [Pg.186]    [Pg.205]    [Pg.226]    [Pg.226]    [Pg.235]    [Pg.243]    [Pg.275]    [Pg.281]    [Pg.306]    [Pg.26]    [Pg.27]    [Pg.30]    [Pg.30]    [Pg.68]    [Pg.73]    [Pg.68]    [Pg.110]    [Pg.153]    [Pg.325]    [Pg.310]    [Pg.348]   


SEARCH



Apoptosis inducers

© 2024 chempedia.info