Apoptosis, neutrophils caspases

Niwa, M., Kara, A., Kanamori, Y, Matsuno, H., Kozawa, O., Yoshimi, N., Mori, H., and Uematsu, T., Inhibition of tumor necrosis factor-ct induced neutrophil apoptosis by cyclic AMP Involvement of caspase cascade. Eur. J. Pharmacol. 371, 59-67 (1999). 

Altznauer, F., Conus, S., Cavalli, A., Folkers, G. and Simon, H. U., 2004, Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis. J Biol Chem 279, 5947-57. Antonsson, B. and Martinou, J. C., 2000, The Bcl-2 protein family. Exp Cell Res 256, 50-7. Benali-Furet, N. L., Chami, M., Houel, L., De Giorgi, F., Vernejoul, F., Lagorce, D., Buscail, L., Bartenschlager, R., Ichas, F., Rizzuto, R. and Paterlini-Brechot, P., 2005, Hepatitis C virus core... 

Takemura et al. [155] described TUNEL positivity, and Hayakawa et al. [152] described caspase-3 positivity in infiltrated and proliferated interstitial cells in an experimental model of MI, suggesting that apoptosis might play an important role in the disappearance of these cells after MI. Consistent with these studies, we found positive reaction for cleaved caspase-3 in neutrophil granulocytes in the interstitium in acute MI in humans (Fig. 4B). 

During chronic inflammatory disease, inflammatory cells (neutrophils, mast cells, macrophages, and lymphocytes) become increasingly more damaging to tissues. Anti-inflammatory action of Bik reduces cell death mediated by immune cell. Proinflammatory cytokine tumor necrosis factor-a (TNF-q) and interleukin-1 (3 (IL-1) cause expression of multiple inflammatory and innate immunity genes for additional cytokines, chemokines, adhesion molecules, and enzymes. Aprotinin has been reported to cause a reduction in apoptosis in vivo by decreasing inflammatory cytokine expression (IL-1, IL-6, and TNF -a) thus preventing caspase-8 activation [81],... 

Mouse Cisplatin 30 mg/kg Apoptosis on day 2 after cisplatin ATN and neutrophil infiltration on day 3 after cisplatin Caspase-1 and 3 activation S3 segment of proximal tubule [203]... 

Apoptotic cell death is regulated by NO and ONOO" in several cell types including myeloid-derived leukocytes such as neutrophils. The biological effects of NO and ONOO" have been recently reviewed [68]. GEA3162 is able to promote apoptotic cell death in human neutrophils in a caspase-dependent manner [69]. The tumor suppressor p53 is suggested to play a crucial role in apoptosis induced by oxidants. However, functional p53 is not a requirement for ONOO -mediated cell death, as GEA3162 induces mitochondrial permeability in a p53-deficient murine bone marrow cell line, Jaws II. GEA3162 activates caspases 3 and 2 which are important for apoptosis to proceed, with roles for caspases 8 and 9, and p38 MAP kinase [70]. 

Watson RW, Rotstein OD, Parodo J, Bitar R, Marshall JC, William R, Watson G The IL-113-converting enzyme (caspase-1) inhibits apoptosis of inflammatory neutrophils through activation of IL-ip. J Immunol 1998 161 957-962. 

Ottonello L, Frumento G, Arduino N, Bertolotto M, Dapino P, Mancini M, Dallegri F Differential regulation of spontaneous and immune complex-induced neutrophil apoptosis by proinflamma-tory cytokines. Role of oxidants, Bax and caspase-3. J Leukoc Biol 2002 72 125-132. 

Antisense disruption of Mcl-l protein levels in human neutrophils can decrease the levels of this survival factor in control or GM-CSF-untreated cells (fig. 2). These decreases in protein levels occur in the absence of changes in the levels of other members of the Bcl-2 family. As Mcl-l levels are decreased by antisense treatment, there is a corresponding increase in the cellular levels of the active form of caspase 3 (fig. 2). There is also a marked correlation between cellular levels of Mcl-l protein and apoptosis (fig. 3). As the levels of this protein are decreased by antisense treatment, so the rate of apoptosis of the cells increases. 

Thornberry NA, Lazebnik Y Caspases Enemies within. Science 1998 281 1312-1316. Yamashita K, Takahashi A, Kobayashi S, Hirata H, Mesner PW Jr, Kaufmann SH, Yonehara S, Yamamoto K, Uchiyama T, Sasada M Caspases mediate tumor necrosis factor-a-induced neutrophil apoptosis and downregulation of reactive oxygen production. Blood 1999 93 674-685. 

Weinmann P, Gaehtgens P, Walzog B Bcl-Xl- and Bax-c<-mediated regulation of apoptosis of human neutrophils via caspase-3. Blood 1999 93 3106-3115. 

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