Antitumor drug

Mitochondrial monoamine oxidase, 1, 253 Mitomycin synthesis, 7, 658, 659 Mitomycin-A, 7, 93 Mitomycin-B, 7, 93 Mitomycin-C, 7, 93 as antitumor drug, 4, 374 Mixed function oxidases, 1, 224 Mobam... 

A new antitumor drug, taxol, has been isolated from the bark of Taxus brevifolia, the Pacific yew tree. Like vinblastine and colchicine, taxol inhibits cell replication by acting on microtubules. Unlike these other antimitotic drugs, however, taxol stimulates microtubule polymerization and stabilizes microtubules. 

DNA cross-linking agents (mainly heterocycles) as antitumor drugs 98CRV2723. 

Natural and synthetic heterocycles as DNA cross-linking agents and antitumor drugs 98CRV2723. 

Pt-complexes with heterocyclic ligands and Pt-chelates as antitumor drugs 99CRV2451. 

As noted above, the steroid nucleus has been a favorite for the design for site directed alkylating antitumor drugs. Thus reaction of prednisolone (62) with anhydride 63 affords the 21 acylated derivative, prednimustine (64). ... 

Kroes, R.A., Abravaya, K., Seidenfeld, J., Morimoto, R.l. (1991). Selective activation of human heat shock gene transcription by nitrosurea antitumor drugs mediated by isocyanate-induced damage and activation of heat shock transcription factor. Proc. Natl. Acad. Sci. USA 88,4825-4829. 

Juliano, R. L., and Me Cullough, H. N. (1980). Controlled delivery of an antitumor drug Localized action of liposome encapsulated cytosine arabinoside administered via the respiratory system, J. Pharmacol. Exp. Ther., 214, 381-387. 

Hansch and Leo [13] described the impact of Hpophihdty on pharmacodynamic events in detailed chapters on QSAR studies of proteins and enzymes, of antitumor drugs, of central nervous system agents as well as microbial and pesticide QSAR studies. Furthermore, many reviews document the prime importance of log P as descriptors of absorption, distribution, metabolism, excretion and toxicity (ADMET) properties [5-18]. Increased lipophilicity was shown to correlate with poorer aqueous solubility, increased plasma protein binding, increased storage in tissues, and more rapid metabolism and elimination. Lipophilicity is also a highly important descriptor of blood-brain barrier (BBB) permeability [19, 20]. Last, but not least, lipophilicity plays a dominant role in toxicity prediction [21]. 

A. Trouet, D. D. Campeneere, R. Burain, M. Huy-brechts, and A. Zeneberch, Desoxyribonucleic acid as carrier of antitumor drugs, in Drug Carriers in Biology and Medicine (G. Gregoriadis, ed.), Academic Press, London, 1979, p. 87. 

Felder TB, McLean MA, Vestal ML et al. Pharmacokinetics and metabolism of the antitumor drug amonafide (NSC-308847) in humans. Drag Metab Dispos 1987 15 773-777. 

O Dwyer, P. J. Stevenson, J. P. Johnson, S. W. Clinical Status of Cisplatin, Carboplatin, and Other Platinum-based Antitumor Drugs. In Cisplatin Chemistry and Biochemistry of a Leading Anticancer Drug Lippert, B., Ed. Wiley-VCH New York 1999, pp 31-72. 

Considerable progress has been made in understanding the chemical principles in Pt-nucleic acid interactions since the discovery of Pt antitumor drugs. At the same time, however, new questions have been raised upon development of novel drugs that violate the early structure-activity relationships. A common feature for various Pt drugs is that their initial binding to nucleic acid fragments seems to be controlled by the... 

De Medina P, Favre G, Poirot M (2004a) Multiple targeting by the antitumor drug tamoxifen a structure-activity study. Curr Med Chem Anti-Cancer Agents 4(6) 491-508... 

The bicyclic imidazotetrazinone temozolomide [13,14] (Fig. 3) is an example of an antitumor drug that acts via decomposition of the triazene inter-... 

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