Other Antitumor and Antiviral Drugs

Tesetaxel (DJ-927) is a fluoro analogue of Taxol currently undergoing Phase I clinical testing for oral treatment of tumors (cf. Chapter 4).  

The first epithilone, a highly potent microtubule stabilizer, in advanced clinical development (Phase II) is ZK-EPO (ZK-219447), while fludelone is still in preclinical trials (cf. Chapter 4). 

2 Other Fluorinated Antitumor Drugs in Development A number of totally synthetic fluorinated molecules are also in clinical development for cancer therapies. There are numerous inhibitors of kinases, some apoptosis inductors, and antifolates. 

Nevertheless, clinical development continues for other cancer treatments. Fluorine and chlorine atoms on the aromatic ring increase plasma half-life of the lead from 30 min to Vandetanib and AZD-2171 are other aminoquinazoline 

Lapatinib, another 4-aminoquinazoline, is a dual ebB l/erbB2 kinase inhibitor. It is currently undergoing Phase III clinical trials for several cancers. 

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