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Reviews antitumor drugs

Hansch and Leo [13] described the impact of Hpophihdty on pharmacodynamic events in detailed chapters on QSAR studies of proteins and enzymes, of antitumor drugs, of central nervous system agents as well as microbial and pesticide QSAR studies. Furthermore, many reviews document the prime importance of log P as descriptors of absorption, distribution, metabolism, excretion and toxicity (ADMET) properties [5-18]. Increased lipophilicity was shown to correlate with poorer aqueous solubility, increased plasma protein binding, increased storage in tissues, and more rapid metabolism and elimination. Lipophilicity is also a highly important descriptor of blood-brain barrier (BBB) permeability [19, 20]. Last, but not least, lipophilicity plays a dominant role in toxicity prediction [21]. [Pg.358]

In this review, we present an introduction to the theory, and exemplify the wide range of problems that can be addressed with some illustrative results from our work in the field of ah initio drug design. The problems addressed are those of activation and DNA binding of the antitumor drug cis-platin (PtCl2(NH3)2), and basic spectrometric data from a family of drugs known as psoralens. [Pg.114]

The reader is referred to other reviews for detailed discussions of the electronic states and luminescence of nucleic acids and their constituents/0 fluorescence correlation spectroscopy/2) spectroscopy of dye/DNA complexes/0 and ethidium fluorescence assays/4,0 A brief review of early work on DNA dynamics as well as a review of tRNA kinetics and dynamics have also appeared. The diverse and voluminous literature on the use of fluorescence techniques to assay the binding of proteins and antitumor drugs to nucleic acids and on the use of fluorescent DNA/dye complexes in cytometry and cytochemistry lies entirely outside the scope of this chapter. [Pg.137]

Over the past 20 years, cis-diamminedichloroplatinum(II), known for more than 145 years, has emerged as the classic compound in the context of antitumor drug therapy. Because it is generally accepted that binding of the compound to DNA is a major requirement for its biological activity, scientists have focused their attention especially on platinum-DNA interactions. In the present review, the latest results... [Pg.175]

The aim of the present contribution is to critically review computational work related to platinum antitumor drugs, published prior to 1998. After a section devoted to molecular-orbital calculations on platinum antitumor complexes and related compounds, we address force-field calculations on platinum adducts with DNA constituents that have been used (mainly in combination with NMR spectroscopy) to evaluate the structure of the adduct. A brief outlook concludes this chapter. [Pg.538]

Mastrobattista, E. Koning, G.A. Storm, G. Immunoliposomes for the targeted delivery of antitumor drugs. Adv. Drug Deliv. Reviews 1999, 40, 103-127. [Pg.1148]

Ding D, Allman BL, Salvi R (2012) Review ototoxic characteristics of platinum antitumor drugs. Anat Rec (Hoboken) 295(11) 1851-1867... [Pg.219]

Quantitative structure-activity relationships of antitumor drugs have been reviewed [781 — 783]. Out of many studies performed by Hansch et al. (e.g. [784 — 789]) some are discussed here to demonstrate how QSAR results can be used to decide on the probability of success of further research. [Pg.132]

Continuing activity on platinum(II) antitumor drugs has resulted in several recent reviews/each of which cover mechanistic aspects. Other reviews include one on metal porphyrins, which features many reactions of 4- and 5-coordinate complexes, and substitution reactions at platinum(II) complexes with asymmetric olefin ligands have been discussed. ... [Pg.130]

E. Wong and C.M. Giandomenico (1999) Chemical Reviews, vol. 99, p. 2451 - Current status of platinum-based antitumor drugs . [Pg.794]

Besides the possible use of such stabilized liposomes as drug carriers (10) another application could be their use as models for the ceTT-cell interaction and as polymeric antitumor agents on a cellular level (11) i.e. trying to mimic the body defense against tumor cells (17J. We hope that this article which in many terms is more a pre- than a review will help to stimulate the discussions on polymeric antitumor agents not only on the al-... [Pg.209]

The in vitro methods by which macromolecular anticancer drug conjugates are evaluated for efficacy are similar to those used to screen for the anticancer activity of low molecular weight compounds. A thorough review of in vitro models used for the evaluation of antitumor therapy was published several years ago [174]. [Pg.86]


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See also in sourсe #XX -- [ Pg.130 ]




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