Antitumor drugs complexes

Pt-complexes with heterocyclic ligands and Pt-chelates as antitumor drugs 99CRV2451. 

So far rhodium complexes have not exhibited the characteristics required for an antitumor drug, perhaps because they often show activity only in a very limited number of tumor models. Nevertheless, activity data for complexes in several oxidation states are encouraging for further studies. 

The reader is referred to other reviews for detailed discussions of the electronic states and luminescence of nucleic acids and their constituents/0 fluorescence correlation spectroscopy/2) spectroscopy of dye/DNA complexes/0 and ethidium fluorescence assays/4,0 A brief review of early work on DNA dynamics as well as a review of tRNA kinetics and dynamics have also appeared. The diverse and voluminous literature on the use of fluorescence techniques to assay the binding of proteins and antitumor drugs to nucleic acids and on the use of fluorescent DNA/dye complexes in cytometry and cytochemistry lies entirely outside the scope of this chapter. 

Syntheses of only a few fluorinated derivatives of alkaloids have been reported in the literature. This is probably due to the difficulty of synthesizing such structurally complex compounds. Most fluorinated alkaloids have been synthesized within the frame of antitumor drugs research. 

Application of the new but already widely employed MS technique of ESI readily allowed the detection of weak noncovalent interactions of antitumor drug-DNA complexes <1999RCM2489, 2002CC556> ESI data were used to derive a semi-quantitative estimate of the relative stability of the DNA complexes formed with 1,3-dithiane analogs. 

Transition-metal based compounds constitute a discrete class of chemotherapeutics, widely used in medicine as antitumor agents.56 Several ruthenium complexes enable the body to catalyze oxidation and reduction reactions, depending on the physiological environment, and have attracted much interest as alternative antitumor drugs in the treatment of cancer cells resistant to cisplatin in cancer... 

Currently, there are interesting new approaches in the design of antitumor drugs a variety of platinum complexes are being designed... 

The combinatorial effects of CyDs and absorption enhancers on the selective transfer of antitumor drug into lymphatic have been demonstrated [36]. When the complex of carmofur... 

Brabec V, Kasparkova J. Modifications of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs. Drug Resist Update. 2005 8 131-146. 

Due to their interesting complex structure and biological activity, indole alkaloids such as strychnine (254), vindorosine (255) and vindoline (256) have attracted considerable attention. Vindoline is a key component in the preparation of the antitumor drugs vincristine and vinblastine (10) [17-19,179-183]. These alkaloids include the same tetracyclic core 257 known... 

Kopf-Maier P, Kopf H (1994) Organometallic titanium, vanadium, niobium, molybdenum and rhenium complexes - early transition metal antitumor drugs. In Fricker SP (ed) Metal Compounds in Cancer Therapy. Chapman Hall, London, pp 109-146... 

The aim of the present contribution is to critically review computational work related to platinum antitumor drugs, published prior to 1998. After a section devoted to molecular-orbital calculations on platinum antitumor complexes and related compounds, we address force-field calculations on platinum adducts with DNA constituents that have been used (mainly in combination with NMR spectroscopy) to evaluate the structure of the adduct. A brief outlook concludes this chapter. 

Somewhat more loosely related to platinum antitumor drugs were EHMO calculations performed on heterobimetallic Pt-Pd complexes with a bridging methylcytosinate anion by Mealli, Randaccio, Lippert, and coworkers [31][32], The calculations served to elucidate the metal-metal and metal-ligand binding interactions, and yielded a qualitative interpretation of the 195Pt-NMR chemical shifts. 

Finally, there are sqnare-planar Pt antitumor ammine complexes (see Platinum-based Anticancer Drugs) with the most well known being ds -dichlorodiammineplatinum(II) (cw-DDP) ds -PtCl2(NH3)2. When dissolved in aqueous solution, the chloro ligands can be partially or completely snbstituted by either H2O or OH, and the pH-dependent kinetics and equilibria have been measnred. ... 

Pt amine complexes were very important in Werner s early studies in coordination chemistry see Coordination Chemistry History) The cis and trans bis(amine) complexes [PtCl2(NH3)2] have taken on special importance with the discovery that they bind to DNA, and the cw-form is in clinical use as an antitumor drug that has led to sharp falls... 

Q. Yan, "Applications of Resonance Raman Spectroscopy to Complexes of Biological and Clinical Significance I. High-Valent Oxo- and Nitridometalloporphyrins II. pu-Oxo Vanadium(III) Dimers III. Antitumor Drug-DNA Intercalators, PhD. Dissertation, University of Houston, 1996. 

---