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Microtubule stabilizing antitumor drug

The total synthesis of the microtubule stabilizing antitumor drug epothilone B was achieved by J. Mulzer et al. who cyclized the 16-membered macrocycle using the Keck macroiactonization. ... [Pg.239]

A new antitumor drug, taxol, has been isolated from the bark of Taxus brevifolia, the Pacific yew tree. Like vinblastine and colchicine, taxol inhibits cell replication by acting on microtubules. Unlike these other antimitotic drugs, however, taxol stimulates microtubule polymerization and stabilizes microtubules. [Pg.538]

See other pages where Microtubule stabilizing antitumor drug is mentioned: [Pg.193]    [Pg.90]    [Pg.215]    [Pg.260]    [Pg.5626]    [Pg.5625]    [Pg.935]    [Pg.96]    [Pg.476]    [Pg.406]    [Pg.251]    [Pg.11]    [Pg.226]    [Pg.2957]   
See also in sourсe #XX -- [ Pg.239 ]



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