Mitomycins synthesis

Mitochondrial monoamine oxidase, 1, 253 Mitomycin synthesis, 7, 658, 659 Mitomycin-A, 7, 93 Mitomycin-B, 7, 93 Mitomycin-C, 7, 93 as antitumor drug, 4, 374 Mixed function oxidases, 1, 224 Mobam... 

Elphamycins, synthetic technology and total synthesis 85MI1. Mitomycins, synthesis 8OYGK1O53 79H(I3)411. 

Kirsch and co-workers (unpublished data) attempted to obtain more information on the nature of ethionine inhibition by studying the reversal of this effect by L-methionine. Graphs showing a pattern of reversal are offered in Fig. 5. At least two significant facts emerge from these data the first is the L-methionine which is known to be an effective competitor of ethionine inhibition of transmethylation reactions does indeed reverse the ethionine effect on mitomycin synthesis. The second fact is that there appears to be a lag period of about 24 hours... 

Investigations of the biosynthesis of the mitomycins are obviously very scanty. Until a research group becomes interested in such studies from an academic point of view, the biogenesis of these unique compounds will continue to remain obscure. It seems fairly certain, at this time, that methylation will prove to be a primary reaction of importance in the terminal steps of mitomycin synthesis. The reactions involved in the transfer of methyl group to the appropriate reactive location of mitosane can be altered and impeded by ethionine. This observation coupled with the fact that extent of ethionine inhibition may be influenced by providing the appropriate concentration of methionine under proper conditions. 

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