Antitumor antibodies

Robins, R A, Laxton, R R., Garnett, M., Price, M. R., and Baldwin, R W (1986) Quantitation of antitumor antibody and antibody conjugate binding activity by competition with fluorochrome-labelled antibody J Immunol Methods 90, 165—172. 

The ADEPT approach has been recently investigated as a means of overcoming the side-effects of using taxol to treat breast cancer by utilizing a /Mactamasc enzyme antitumor antibody conjugate and a cepham sulfoxide derivative of taxol (PROTAX). The localized /Mactamase enzyme, which is not normally found in any other tissues, ensures selective release of taxol at the tumor site. The prodrag is almost as effective as... 

Adhesion Inhibition of integrin-mediated adhesion Chang and Chambers [105] Antitumor antibodies inhibit adhesion Blumenthal et al. [106]... 

T, tumor cells alone TAp or TAtu, cells sensitized with anti-Forssman IgM or antitumor antibody, respectively TCop or TChu. cells treated with guinea pig or human serum (GPC or HuC), respectively TAC, cells sensitized with antibody and treated with complement. 

Preparation and use of DTPA-coupled antitumor antibodies radiolabelled with yttrium-90. In Antibody-Mediated Delivery Sytems, Hnatowich, D.J., Snook, D., Rowlinson, G., Stewart, S., Epentos, A.A., Eds. Marcel Dekker, Inc. New York, 1988 353-374. 

Larson, S.M. Carrasquillo, J.A. Krohn, K.A. Diagnostic imaging of malignant melanoma with radiolabeled antitumor antibodies. JAMA 1983, 249, 811-812. 

Slavin-Chiorini DC, Kashmiri SVS, Lee HS, Milenic DE, Poole DJ, Bemon E, Schlom J, Horan Hand P. A CDR-grafted (humanized) domain-deleted antitumor antibody. Cancer Biother Radiopharm 1997 12 305-316. 

Varadarajan, A., Sharkey, R. M., Goldenberg, D. M., and Hawthorne, M. R 1991. Conjugation of phenyl isothiocyanate derivatives of carborane to antitumor antibody and in vivo localization of conjugates in nude mice. Bioconjugate Chem., 2, 102-10. 

Panorex was more efficacious in the treatment of minimal residual disease and micrometastases (53,54) than in bulky metastatic disease (55). This finding is widely anticipated as a paradigm that will be broadly applicable to other antitumor antibodies. 

Interestingly, all these monoclonal antibodies have a poor antitumor activity when used as single agents, with overall response rates of about 10%. Thereby, these monoclonal antibodies have all been approved in combination with classical cytotoxic agents or radiation therapy. 

Begent, R. H. J., Green, A. J., Bagshawe, K. D., Jones, B. E., Keep, P. A., Searle, F., Jewkes, R. F., Barrat, G. M., and Ryman, B. E. (1982). Liposomally entrapped second antibody improves tumor imaging with radiolabelled (first) antitumor anti-body. Lancet, 2, 739-742. 

Hashimoto, Y., Sugawara, M., Masuko, T., and Hojo, H. (1983). Antitumor effect of actinomycin D entrapped in liposomes bearing subunits of tumor-specific monoclonal immunoglobulin M antibody. Cancer Res., 43, 5328-5334. 

K., Abe, O., and Saito, K. (1987). Antitumor effect of adria-mycin entrapped in liposomes conjugated with anti-human alfa-fetoprotein monoclonal antibody, Cancer Res., 47, 4471-4477. 

Gemtuzumab zoqamicin -monoclonal antibody against CD33 with calicheamicin (antitumor antibiotic) -fevers and chills -hypotension -grade IV neutropenia and thrombocytopenia -LFT elevations ... 

Baselge, ]., et al., "Recombinant Humanized Anti-HER2 Antibody (HERCEPTIN) Enhances the Antitumor Activity of Paclitaxel and Doxorubicin Against HER2/neu Overexpressing Human Breast Cancer Xenografts," Cancer Res., 58, 2825-2831 (1998). 

Fig. 8.17. Mechanism of bioactivation of self-immolative carbamate prodrugs of cytotoxic amines. A bacterial nitroreductase coupled to a tumor-directed antibody reduces the prodrug to a hydroxylamine (Reaction a), which breaks down spontaneously to liberate the antitumor...

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