Adhesion integrin-mediated

Inflammation. Figure 1 Sequence of events in the recruitment of leukocytes in postcapillary venules adjacent to injured tissue. At the site of lesion, diverse reactive substances stimulate the endothelium to produce inflammatory cytokines, chemoattractants and other inflammatory mediators. The cytokine-activated endothelium expresses adhesion molecules that lead to the low affinity interactions between leukocytes and endothelium, which is mediated by selectins and described as rolling. Subsequently integrins mediate the firm adhesion of leukocytes, which allows emigration of the cells from venules into the interstitial compartment. Activated mast cells, PMNs and macrophages secrete cytokines (TNFa), lipid mediators (LTB4) and other inflammatory players (histamine, NO). 

Integrins Mediate Adhesion of Neutrophils to Endothelial Cells... 

COLl domain of type XXIII collagen contains multiple copies of a conserved KGD motif used for integrin-mediated cell adhesion by collagen type XVII. ... 

Dutta AS, Gormley JJ, Coath M, et al. Potent cyclic peptide inhibitors of VLA-4 (a4 pi Integrin)-mediated cell adhesion. Discovery of compounds like cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg) (ZD7349) compatible with depot formulation. 7 Pept Sci 2000 6 398-412. 

Collaborative signaling integrin-mediated cell adhesion modulates signal transduction by other receptors (e.g., receptor tyrosine kinases). 

The chemical part of the adhesion process dictates that in designing a surface for attachment of cells, one must seek to stimulate an active interaction between the surface and the scaffold. The surface properties of the scaffold are our main concerns. The surface should mimic the natural support structures on the human body. Extracellular matrix (ECM) provides cells with an interactive structure onto which they can adhere. This process (referred to as integrin-mediated binding) is a basis of cell growth. 

Chen Q, Kinch MS, Lin TH et al. Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J of Biol Chem 1994 269 26602. 

Micro-nanopatterned Surfaces A Deeper Structural Insight into Integrin-Mediated Adhesion... 

Fig. 8 Simplified schematic of cell adhesion through integrin-mediated communication with the...

Gronowicz, G, and McCarthy, M. B., Response of human osteoblasts to implant materials integrin-mediated adhesion. /. Orthop. Res. 14 (6), 878-887 (1996). 

Pelagalli, A., Belisario, M. A., Squillacioti, C., Della Morte, R., d Angelo, D., Tafuri, S., Lucisano, A., and Staiano, N. (1999). The mycotoxin fumonisin B1 inhibits integrin-mediated cell-matrix adhesion. Biochimie 81(10), 1003-1008. 

Adhesion Inhibition of integrin-mediated adhesion Chang and Chambers [105] Antitumor antibodies inhibit adhesion Blumenthal et al. [106]... 

Chang PL, Chambers AE Transforming JB6 cell exhibit enhanced integrin-mediated adhesion to osteopontin. I Cell Biochem 2000 78 8-23. 

Giblin, P. A., and Kelly, T. A. (2001). Antagonists of /32 integrin-mediated cell adhesion. 

In addition, it is part of the integrin-mediated platelet adhesion (Lahav et al, 2000). A threonine phosphorylation has been described for the PDI localized in the endoplasmatic reticulum (Quemeneur et al., 1994). 

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