Tumors, imaging

Tumble test Tumbling Tumeric Tumor antigens Tumor cells Tumor imaging Tumor necrosis Tumor necrosis factor... 

Na Mc O, are used for imaging of the thyroid gland. GaUium-67-citrate [41183-64-6] is used for tumor imaging. Several other appHcations of nuclear... 

Begent, R. H. J., Green, A. J., Bagshawe, K. D., Jones, B. E., Keep, P. A., Searle, F., Jewkes, R. F., Barrat, G. M., and Ryman, B. E. (1982). Liposomally entrapped second antibody improves tumor imaging with radiolabelled (first) antitumor anti-body. Lancet, 2, 739-742. 

Uliana, J. A., Gamble, R. C., and Baldeschwieler, J. D. (1983). Liposomal blockade of the reticuloendothelial system Improved tumor imaging with small unilamellar vesicles. Science. 220. 502-505. 

Application of [Ni(CN)4]2 as a tumor imaging agent has been reported.4 4... 

Kimura and coworkers have also developed hybrid-type polymersomes composed of polysarcosine-b-PLA ( lactosomes ) [242-243]. The lactosomes are fully biodegradable due to the equipped metabolic pathway for sarcosine and lactic acid. Hence, the lactosome is preferred for in vivo applications rather than for in vitro studies. Indeed, they have demonstrated a potential utility of lactosomes as a contrast agent for in vivo liver tumor imaging [243]. Lactosomes labeled with indocyanine green showed high escape ability from RES, were found to be stable in... 

Otsuka, F.L., and Welch, M.J. (1987) Methods to label monoclonal antibodies for use in tumor imaging. Nucl. Med. Biol. 14, 243-249. 

Tc(CN—R)e] and other cationic complexes have also been found to be taken up by various tumors by mechanism and kinetic rate laws comparable to those found in myocardial uptake. Therefore, these compounds are investigated for tumor imaging, and are studied in particular for breast-tumor imaging. " ... 

M. Ogawa, K. Hatano, S. Oishi, Y. Kawasumi, N. Fujii, M. Kawaguchi, R. Doi, M. Imamura, M. Yamamoto, K. Ajito, T. Mukai, H. Saji, K. Ito, Direct electrophilic radiofluorination of a cyclic RGD peptide for in vivo alpha(v)beta(3) integrin related tumor imaging, Nucl. Med. Biol. 30 (2003) 1-9. 

C. P. Simpson, G.D. Bowers, J.J. Olson, M.M. Goodman, Radiolabeled amino acid-sfor tumor imaging with PET Radiosynthesis and biological evaluation of2-amino-3-[F-18]fluoro-2-methylpropanoic acid and 3-[F-18]fluoro-2-methyl-2-(methylamino) propanoic acid, J. Med. Chem. 45 (2002) 2240-2249. 

Since its first in vivo evaluation [3], the metabolic radiotracer f FlFOG has become the most important radiopharmaceutical in clinical PET and is predominantly used for tumor imaging, particularly for the estimation of glucose uptake... 

Initially choline, (CH3)3N+CH2CH20H = trimethyl-2-hydroxyethylamminium, was introduced for tumor imaging labeled with [ C] by Hara et al. [175,176]. However, the short half-life of [ C] (20 min) limits its use in institutions with a cyclotron on site. This led to the development of [ F] (half-life 110 min) labeled choline taking also advantage of the better physical properties for imaging of F compared with [ C] [178]. Two compounds of p F]-labeled choline analoga are currently in use 2-[ F]-fluoroethyl-dimethyl-2-hydroxyethyl-ammo-nium ([ F]-FEC) and [ F]-fluoromethyl-dimethyl-2-hydroxyethylammonium choline (p F]-FCH) [178,179]. 

Radiolabeled amino acids have been introduced as SPECT and PET tracers that allow a precise delineation of brain tumor in cerebral gliomas and differentiation of tumor tissue and edema. Radiolabeled amino acids are taken up by specific amino acid transporters in glioma cells [198-201]. Recently 0-(2-[ F] fluorethyl)-L-tyrosin (p FjFET) has been introduced as PET brain tumor imaging tracer [202,203]. 

M. Piert, H.J. Machulla, M. Picchio, G. Reischl, S. Ziegler, P. Kumar, H.J. Wester, R. Beck, A.J. McEwan, L.l. Wiebe, M. Schwaiger, Hypoxia-specific tumor imaging with F-fluoroazomycin arabinoside, J. Nucl. Med. 46(1) (2005) 106-113. 

H.J. Wester, M. Herz, W. Weber, P. Heiss, R. Senekowitsch-Schmidtke, M. Schwaiger, G. Stocklin, Synthesis and radiopharmacology of 0-(2-[ F]fluor-oethyl)-L-tyrosine for tumor imaging, J. Nucl. Med. 40(1) (1999) 205-212. 

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