Transporter associated with antigen processing

Kuzushita N, Hayashi N, Kanto T, Ta-kehara T, Tatsumi T, Katayama K et al. Involvement of transporter associated with antigen processing 2 (TAP2] gene polymorphisms in hepatitis C virus infection. Gastroenterology 1999 116[5] 1149-1154. 

HSAB and sulfo-HSAB have been used to investigate serum amyloid A (Cai et al., 2007), the functional role of C-terminal sequence elements in the transporter associated with antigen processing (Ehses et al., 2005), and the kinetics of intermolecular interactions during cytochrome C protein folding (Nishida et al., 2004). 

Abele, R., and Tampe, R., 2004, The ABCs of immunology structure and function of TAP, the transporter associated with antigen processing, Physiology (Bethesda) 19 216-224. 

Lou, Y., Vitalis, T. Z., Basha, G., Cai, B., Chen, S. S., Choi, K. B., Jeffries, A. P., Elliott, W. M., Atkins, D., Seliger, B., and Jefferies, W. A., 2005, Restoration of the expression of transporters associated with antigen processing in lung carcinoma increases tumor-specific immune responses and survival, Cancer Res. 65 7926-7933. 

Eukaryotic cells also have additional transport mechanisms. One of these is an ABC transporter (p. 417) known as the transporter associated with antigen processing (TAP). It carries small polypeptides generated by proteasomes from the cytosol into the ER for export and binding to MHC Class I molecules and subsequent presentation to the immune system (Fig. 31-15).540 602... 

Ornithine decarboxylase catalyzes the transformation of ornithine to the polycationic bases, putresine, spermine, and spermidine. These compounds exert regulatory effects on cell growth. It has been shown that quercetin (10 to 30 pmol/mouse) markedly suppressed the stimulatory effect of the transporters associated with antigen processing (TPA) on ornithine decarboxylase (ODC) activity and on skin tumor formation in mice initiated with dimethylbenzanthracene. Such inhibition may be related to the activation of the catalytic site, which is under nonconventional regulation by small molecules. Also, the synthetic flavonoid flavone acetic acid was shown to inhibit the activity of ODC in stimulated human peripheral blood lymphocytes and human colonic lamina propria lymphocytes. 

In a study of the Qa-2-expression regulation by the transporter associated with antigen processing (TAP) protein, Ke and Warner [14] reported the monitoring of preimplantation embryos from TAP-1 knockout and normal mice by IPCR and RT-PCR. IPCR was carried out as described by McElhinny et al. [17]. Again, IPCR proved its potential as a valuable tool for the analysis of protein expression on the cell surface from small numbers (2-20) of one-cell and two-cell embryos, as well as blastocystes. 

B. Lankat-Buttgereit and R. Tampe. The transporter associated with antigen processing function and implications in human diseases. Physiol Rev, 82 187-204, 2002. 

Tandem affinity purification also transporter associated with antigen processing... 

Saveanu, L., Daniel, S., and van Endert, P.M. (2001) Distinct functions of the ATP binding cassettes of transporters associated with antigen processing a mutational analysis of Walker A and B sequences. The Journal of Biological Chemistry, 276 (25), 22107-22113. 

Gaudet, R. and Wiley. D.C. (2001) Structure of the ABC ATPase domain of human TAPI, the transporter associated with antigen processing. The EMBO Journal, 20 (17), 4964—4972. 

Table 11.1. Ranking of amino acids unfavorable (a) or favorable (b) for peptide recognition by human transporter associated with antigen processing (TAP), as identified by screening of 0/X peptide libraries [20].

Muller KM, Ebensperger C, Tampe R (1994) Nucleotide binding to the hydrophilic C-tcrminal domain of the transporter associated with antigen processing (TAP), J Biol Chem 269 14032-14037. 

Koopmann JO, Post M, Neefjes JJ, Hammerling GJ, Momburg F (1996) Translocation of long peptides by transporters associated with antigen-processing (TAP), Eur J Immunol 26 1720-1728. 

Uebel S, Meyer TH, Kraas W, Kienle S, Jung G, Wiesmuller KH, Tampe R (1995) Requirements for peptide binding to the human transporter associated with antigen-processing revealed by peptide scans and complex peptide libraries, J Biol Chem 270 18512-18516. 

Smith DC, Gallimore A, Jones E et al. (2002). Exogenous peptides delivered by ricin require processing by signal peptidase for transporter associated with antigen processing-independent MHC class 1 -restricted presentation. J Immunol, 169, 99-107. 

Lehner PJ, Karttunen JT, Wilkinson GW, Cresswell P (1997) The human cytomegalovirus US6 glycoprotein inhibits transporter associated with antigen processing-dependent peptide translocation. Proc Natl Acad Sci USA 94 6904 6909... 

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