Anticholinergics irritable bowel syndrome

These drugs have weaker anticholinergic activity than atropine however, they have a significantly more expressed antispastic action. They are used for treating so-called irritable bowel syndrome and diarrhea. 

Constipation may be caused by slow intestinal transition, pelvic floor dysfunction, bowel dysfunction like irritable Bowel syndrome and tumours, but can also be secondary to other diseases and life conditions. Many medicines cause constipation, for example opiates, calcium channel blockers and drugs with anticholinergic effects, e.g. antidepressants. 

Several organs are the target for the anticholinergic (anti-muscarinic) activity of the tricyclic antidepressants. They constitute the most common and troublesome adverse effects of the tricyclic antidepressants, but the peripheral anticholinergic actions can also be put to therapeutic use in conditions such as irritable bowel syndrome, premature ejaculation, and nocturnal enuresis. 

Indications Irritable bowel syndrome Category Anticholinergic Muscarinic antagonist Half-life initial 1.8 hours terminal 9-10 hours Clinically important, potentially hazardous interactions with anticholinergics, arbutamine... 

Trade names Gastrodyn Robinul (Forte) Sroton Strodin Indications Duodenal ulcer, irritable bowel syndrome Category Anticholinergic Muscarinic antagonist Nondepolarizing muscle relaxant Half-life N/A... 

Atropine is a GI anticholinergic combination. This combination promotes peripheral antichohnergic/antispasmodic action (decreases GI motility) and provides mild sedation. It is possibly effective for treatment of irritable bowel syndrome and acute enterocolitis. It also may be useful as adjunctive therapy for duodenal ulcer. 

Dicyclomine is an anfispasmodic agent that relieves smooth-muscle spasm of the G1 tract through anticholinergic effects and direct action on G1 smooth muscle. It is indicated in the treatment of functional bowel/irritable bowel syndrome (e.g., irritable colon, spastic colon, and mucous colitis). 

Methscopolamine is a quaternary anticholinergic agent that competitively inhibits action of acetylcholine at muscarinic receptors. Methscopolamine, an anticholinergic agent with gastrointestinal antispasmodic properties (2.5 to 5 mg p.o. one-half hour before meals), is used as an adjunctive therapy in peptic ulcer and irritable bowel syndrome (IBS). 

---