Premature Ejaculation

Since the introduction of the first approved SSRI, fluoxetine (1) in 1987 [9], a number of SSRIs have been developed for the treatment of depression [2], Currently, the five most commonly prescribed SSRIs are fluoxetine, escitalopram (2, S-enantiomer of citalopram), sertraline (3), paroxetine (4) and fluvoxamine (5). Recent effort in the clinical development of new SSRIs has focused on the treatment of premature ejaculation (PE) by taking advantage of the ejaculation-delaying side effects of SSRIs [10]. Although SSRIs have been prescribed off-label to treat this condition, an SSRI with rapid onset of action and rapid clearance could be preferred for on-demand treatment of PE [11,12]. Dapoxetine (LY210448, 6), an... 

The recent approval of the SNRI duloxetine for the treatment of diabetic neuropathy reinforces the utility of this drug class in the treatment of neuropathic pain. Other largely untapped areas which remain to be exploited with this drug class include sexual dysfunction, such as premature ejaculation, irritable bowel syndrome, obesity, neurodegenerative diseases such as Parkinson s disease, restless leg syndrome, and substance abuse and addiction. It is apparent that considerable opportunities for drug discovery will exist in this area for some time to come. 

Blurred vision, diarrhea, headache, anorexia, premature ejaculation, impotence, dyspepsia Rare... 

Benzocaine has been termed by the FDA as one of the most widely used and safest external analgesic and that the incidence of sensitivity of benzocaine is quite low. If s male genital desensitizing product has been termed as premature ejaculation remedy. Benzocaine when applied on the penis aids in temporarily slowing the onset of ejaculation. 

N.A. Psoraline, isopsorlin, bavachin." Treat impotence, premature ejaculation. 

N.A. Epimedium sagittatum Jack. No information is available in the literature. Internally for asthma, bronchitis, cold or numb extremities, arthritis, lumbago, impotence, premature ejaculation, high blood pressure.345... 

N.A. Morinda didyma L. M. fistulosa L. M. punctata L. Morindin, vitamin C." Treat impotence and premature ejaculation in men, infertility. 

Excessive sweating, severe cough, shortness of breath, asthma, palpitations, uterine bleeding, spermatorrhea, premature ejaculation, large amount of leukorrhea, incontinence of urine, enuresis, diarrhea, prolapse of rectum and uterus. 

Asthma, pulmonary emphysema, chronic bronchitis, hyperventilation, arrhythmia, tachycardia, insomnia, colitis, chronic enteritis, dysentery, food allergy, premature ejaculation, spermatorrhea, urinary incontinence and enuresis. 

When Kidney-Qi and Kidney-Yang are weak, premature ejaculation, spermatorrhea, incontinence, enuresis and diarrhea may be present. 

These are the substances that particularly stabilize the Kidney-essence. They are used in the treatment of frequent night urination, enuresis, spermatorrhea and premature ejaculation in conditions of Kidney-Yang or Kidney-Qi deficiency. 

Sha Yuan Zi, Tu Si Zi and Rou Gui particularly warm the Kidney-Yang. They can be selected in conditions of frequent urination in the night, enuresis, impotence, spermatorrhea and premature ejaculation due to Kidney-Yang deficiency. 

Lian Xu is another assistant. It is sweet, neutral and astringent, and enters the Kidney and Bladder meridians. Lian Xu is the first choice for stabilizing the semen and treating spermatorrhea and premature ejaculation. 

These data suggest that antidepressant-induced sexual dysfunction is more likely to be associated with agents that greatly potentiate 5HT neurotransmission. This notion is supported by the results of a 6-week doubleblind study of 24 men with premature ejaculation, in which paroxetine (20 mg/day) increased latency to ejaculation six-fold while mirtazapine (30 mg/day) had minimal effect (4). In a randomized, 8-week, double-blind, placebo-controlled study in 450 patients with major depression, fluoxetine (20 -0 mg/day) significantly impaired sexual function, while the noradrenaline re-uptake inhibitor reboxetine had no effect (5). 

Several organs are the target for the anticholinergic (anti-muscarinic) activity of the tricyclic antidepressants. They constitute the most common and troublesome adverse effects of the tricyclic antidepressants, but the peripheral anticholinergic actions can also be put to therapeutic use in conditions such as irritable bowel syndrome, premature ejaculation, and nocturnal enuresis. 

The ability of SSRIs to cause delayed ejaculation has been used in controlled trials of men with premature ejaculation (61,62). Of the SSRIs, paroxetine and sertraline produced the most benefit in terms of increase in time to ejaculation, but fluvoxamine did not differ from placebo. Clomipramine was more effective than the SSRIs but caused most adverse effects. From a practical point of view many patients might prefer to take medication for sexual dysfunction when needed rather than on a regular daily basis, and it would be of interest to study the beneficial effects of SSRIs on premature ejaculation when used in this way. 

Kim SC, Seo KK. Efficacy and safety of fluoxetine, sertraline and clomipramine in patients with premature ejaculation a double-blind, placebo controlled study. J Urol 1998 159(2) 425-7. 

Impotence and delayed ejaculation in men and difficulty in achieving orgasm in two women have been reported with a variety of MAO inhibitors used to treat narcolepsy (28), phobic anxiety (29), and depression (30-32). Sexual symptoms are often dose-related and there is a delicate interplay between psychic and pathophysiological influences. In men with premature ejaculation this effect may even be considered therapeutic. 

Drugs that potentiate serotonin function can cause ejaculatory delay in men, and this has led to the use of SSRIs to treat premature ejaculation (SEDA-26, 13). Venlafaxine is also reported to cause problems with ejaculation during routine use and its efficacy has been studied in a placebo-controlled, crossover study in 31 men with ejaculation latencies of less than 2 minutes (25). Both placebo and venlafaxine (75 mg/day of the XL formulation) significantly increased latency to ejaculation over baseline, placebo by 2 minutes and venlafaxine by 3 minutes there was no difference between the two treatments. The authors concluded that venlafaxine is not effective for the management of premature ejaculation. However, the small number of subjects studied and the large placebo effect makes this conclusion tentative. It does appear, however, that the effect of venlafaxine on ejaculation delay is probably less striking than, for example, that of paroxetine. 

Kilic S, Ergin H, Baydinc YC. Venlafaxine extended release for the treatment of patients with premature ejaculation a pilot, single-blind, placebo-controlled, fixed dose crossover study on short-term administration of an antidepressant drug. Int J Androl 2005 28 47-52. 

Obsessive compulsive disorder, panic disorder, generalized anxiety disorder, bulimia nervosa, social anxiety disorders, post-traumatic stress disorder, dementia, dysthymia, premature ejaculation. Citalo-pram (investigational) is used for dementia, smoking cessation, ethanol abuse, OCD in children with diabetic neuropathy. Sertraline and Sarafem (contains fluoxetine) are also used to treat premenstrual dysphoric disorder. 

Premature ejaculation is another widespread male sexual disorder. It is defined as the persistent or recurrent ejaculation of semen with minimal sexual stimulation before, on, or shortly after vaginal penetration, and before the person or his partner desires it (119). Although less publicized than erectile dysfunction, premature ejaculation is believed to be the most common male sexual disorder. The prevalence rate.is estimated at 30-40%of "normal" men (120). 

Also for impotence and premature ejaculation, add Herba Allii Fistulosi (Cong Bai), Semen Allii Tuberosi (Jiu Zi), Actinolitum (YangQi Shi), Herba Epimedii (Yin YangHuo), and Rhizoma Curculiginis Orchoidis (Xian Mao). 

Can lead to premature ejaculation in males who use it primarily to reduce tension... 

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