Anticarcinogenic property

Biocatalytic access to both antipodal sulfoxides was exploited in total syntheses of bioactive compounds, which is outlined in some representative examples. Biooxidation of functionalized dialkyl sulfides was utilized in the direct synthesis of both enantiomers of sulforaphane and some analogs in low to good yields and stereoselectivities (Scheme 9.27) [206]. This natural product originates from broccoli and represents a potent inducer of detoxification enzymes in mammalian metabolism it might be related to anticarcinogenic properties of plants from the cruciform family. All four possible stereoisomers of methionine (R = Me) and ethionine sulfoxides... 

They also form complexes with bile acids and reduce their absorption in vitro. The anticarcinogenic properties of soybean saponins are apparently related to their ability to bind with bile acids. 

Glucosinolates Myrosinase Vegetable seeds Positive or negative character, e.g. antinutritional, toxic and off-flavour effects, as well as anticarcinogenic properties... 

Banner et al., (21) found that selenium did not influence the acute alterations induced by 2-acetylaminofluorene or methylazoxymethanol and suggested that the anticarcinogenic properties of selenium were due to a mechanism other than an interference with carcinogen activation and interaction with cellular macromolecules. 

Curcumin is reported to prevent DNA damage, even in individuals who may be genetically susceptible to the toxic effects of xenobiotic exposures, and is also able to exert antimutagenic/anticarcinogenic properties at levels as low as 0.1-0.5% in the diet (Polasa et al., 2004). 

Tannic acid is not consistently absorbed from intestinal mucosa or from the skin. Enhanced absorption rates can be seen in denuded skin and mucus membranes. Tannic acid can cause hardening of the gastrointestinal mucosa. This hardening can result in reduced gastrointestinal absorption of nutrients as well as of xenobiotics. Tannic acid has been experimentally shown to be able to reduce the carcinogenic potency of some amine derivatives and polycyclic aromatic hydrocarbons in laboratory animals. Tannic acid s anticarcinogenic properties appear to be mediated through the modulation of enzymes involved in xenobiotic metabolism. 

Cauliflower has a very high waste index (Kulkami et ah, 2001) and is an excellent source of protein (16.1%), cellulose (16%), and hemicellulose (8%) (Wadhwa et ah, 2006). It is considered as a rich source of dietary fiber and it possess both antioxidant and anticarcinogenic properties. Phenolic compounds and vitamin C are the major antioxidants of brassica vegetables, due to their high content and high antioxidant activity (Podsedek, 2007). Lipid-soluble antioxidants (carotenoids and vitamin E) are responsible for up to 20% of the brassica total antioxidant activity. The level of nonstarch polysaccharide (NPS) in the upper cauliflower stem is similar to that of the floret and both are rich in pectic polysaccharides, while the cauliflower lower stem is rich in NPS due mainly to cellulose and xylan deposition (Femenia et ah, 1998). 

The discovery of anticarcinogenic properties of many plant-borne compounds present in food is undoubtedly one of the most important developments, encouraging the hope that the cancer death toll can be diminished. The fact that these substances are found in liked and widely appreciated food products should facilitate the utilization of their precious chemopreventive properties. 

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