Anticarcinogenic compounds

No consideration has been given to possible synergistic effects with the various anticarcinogenic agents. It is possible that combinations of relatively small nontoxic doses of the anticarcinogenic compounds would protect against chemical-induced neoplasia for a variety of carcinogens. 

Particular attention has recently focused on C18 2, 9-cis, ll-trans, conjugated LNA (CLNA) as a natural anticarcinogenic compound of natural fat of animal (bovine) food. 

Wu TS, Shi LS, Kuo SC (1999b) Alkaloids and other constituents from Tribulus terrestris. Phytochemistry 50(8) 1411-1415 Yagudaev MR, Khalmirzaev MM, Yunusov SYu (1983) NMR study of alkaloids. V. C NMR spectra and reconsideration of the structures of 11- and 10-hydroxypleiocarpamines and the structures of new alkaloids ffom Vinca erecta. Chem Nat Compd 19(4) 454- 58 Yagura T, Motomiya T, Ito M, Honda G, lida A, Kiuchi F, Tokuda H, Nishino H (2008) Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum. J Nat Med 62(2) 174-178... 

Yagura T, Motomiya T, Ito M, Flonda M, lida A, Kiuchi F, Tokuda H, Nishino H (2008) Anticarcinogenic compounds in the Uzbek medicinal plant. Helichrysum maracandicum. J Nat Med 62 174... 

Heteropolyacids (HPA) are the unique class of inorganic complexes. They are widely used in different areas of science in biochemistry for the precipitation of albumens and alkaloids, in medicine as anticarcinogenic agents, in industry as catalysts. HPA are well known analytical reagents for determination of phosphoms, silica and arsenic, nitrogen-containing organic compounds, oxidants and reductants in solution etc. 

There is considerable evidence to suggest that selenium compounds are anticarcinogens. For one thing, tests with laboratory animals show that the incidence and size of malignant tumors are reduced when a solution containing Na2Se03 is injected at the part per million level. Beyond that evidence, statistical studies show an inverse correlation between selenium levels in the soil and the incidence of certain types of cancer. 

Biocatalytic access to both antipodal sulfoxides was exploited in total syntheses of bioactive compounds, which is outlined in some representative examples. Biooxidation of functionalized dialkyl sulfides was utilized in the direct synthesis of both enantiomers of sulforaphane and some analogs in low to good yields and stereoselectivities (Scheme 9.27) [206]. This natural product originates from broccoli and represents a potent inducer of detoxification enzymes in mammalian metabolism it might be related to anticarcinogenic properties of plants from the cruciform family. All four possible stereoisomers of methionine (R = Me) and ethionine sulfoxides... 

Chapter 4 - Propolis has been used for as a traditional medicine in Eastern Europe as an antifungal, antimicrobial, antiviral, anti-inflammatory, and anticarcinogenic agent. The author isolated three cinamic acid derivatives and one flavanol derivative from Brazilian propolis and determined their structures by spectroscopic analysis. Results were assayed, the anticancer drug potential of these compounds to identify new drug candidates, by determining the... 

Food-derived anticarcinogens, conjugated dienoic derivatives of linoleic acid, 262-270 Food quality health concerns, 5-6 maintenance by natural and synthetic compounds, 56-76 molecular s proaches to study, 1-6 related to antimicrobial peptides, 303-318 Foodbome pathogens, ionizing radiation, 296-298 Free radical(s) beef flavor peptides, 89-91 oxidation generating system, 88-89,91/ protein composition, 88-89,91/... 

Recently, Germain et al. (90) studied the in vivo metabolism of diallyl disulfide (DADS), a garlic compound claimed to have anticarcinogenic effects. After oral administration of a single dose of 200mg/kg, metabolites were measured in the stomach, liver, plasma, and urine by GC coupled with MS over 15 days. DADS was detected in almost all analyzed tissues within the first hours. In addition, the metabolites allylmercaptan (AM) and allyl methyl sulfide (AMS) were detected. The Cmav of the metabolites were higher than that of DADS (1.46 pg/mL). The %ax for DADS was estimated to be less than one hour, whereas this time increased to 24 hours for AM and AMS (90). 

Peptide a-oxo acids, a-oxo esters, and a-oxoamides are also potent inhibitors of cysteine and serine proteases. Oxidation of peptide a-substituted carboxylic acid derivatives provides a general route to these compounds (Section 15.1.5). Peptide hydroxamic acids have been shown to be inhibitors of metalloproteinase and some have been reported to have antibiotic, anticarcinogenic, and antiviral activities. Peptide hydroxamic adds may be prepared by solution and solid-phase methods using a variety of resins (Section 15.1.6). a-Aminoboronic acids may be prepared by several routes and are reported to be inhibitors of aminopepti-dases. Procedures have been developed for their incorporation into peptides (Section 15.1.7). 

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