Antibody functions

Davies, D.R., Metzger, H. Structural basis of antibody function. Annu. Rev. Immunol. 1 87-117, 1983. 

Volume 200. Protein Phosphorylation (Part A Protein Kinases Assays, Purification, Antibodies, Functional Analysis, Cloning, and Expression)... 

Pindzola BA, Nguyen AT, Reppy MA (2006) Antibody-functionalized polydiacetylene coatings on nanoporous membranes for microorganism detection. Chem Commun 8 906-908... 

Anodic Stripping Voltammetry of Anti-VI Antibody Functionalized CdTe Quantum Dots for Specific Monitoring of Salmonella enterica serovar Typhi... 

McDevitt MR, Chattopadhyay D, Kappel BJ, Jaggi JS, Schififinan SR, Antczak C, Njardarson JT, Brentjens R, Scheinberg DA (2007) Tumor targeting with antibody-functionalized, radiolabeled carbon nanotubes. J. Nucl. Med. 48 1180-1189. 

Since the first successful examples of tailored antibodies that catalyze chemical transformations, great attention has been drawn to this field of research. In the last two decades, a large number of antibodies that are able to catalyze a variety of chemical processes have been investigated and the mechanism of those abzymes has greatly been elucidated thanks to structural studies. Indeed, a good number of three-dimensional structures were solved during the past few years, which made it possible to elucidate the mechanism whereby the catalytic antibodies function. 

Improving Antibody Function Using Bispecific Antibodies... 

Marzocchi-Machado CM, Polizello AC, Azzolini AE, Lucisano-Valim YM. The influence of antibody functional affinity on the effector functions involved in the clearance of circulating immune complexes anti-BSA IgG/BSA. Immunol Invest 1999 28(2-3) 89—101. 

Stem of Y contains the Fc (fragment, crystallizable) region, which binds to various cell receptors and complement proteins, regulating antibody function... 

Antibody-Functionalized Nanotube Membranes for Selective Enantiomeric Separations.698... 

In principle, nanotubes with the Cig inside extract any lipophilic molecule. This ability to sequester lipophilic molecules can be viewed as a generic type of extraction selectivity, which might be useful in some apphcations. However, nanotubes that have molecular-recognition capability and extract only one particular molecule from solution might also be useful. We have shown that antibody-functionalized nanotubes can provide the ultimate in extraction selectivity—the extraction of one enantiomer of a chiral drug molecule. 

There are many unresolved questions over the relationship of carbohydrate structure to antibody activity, kinetics and specificity. However, it is evident that the carbohydrate structure greatly affects the antibody functions. Attempts at improving the functions of antibodies by means of carbohydrate modification are now viewed as valuable from the standpoint of their potential for commercialization [43,44]. 

A golden bullet Selective targeting of toxoplasma gondii tachyzoites using antibody-functionalized gold nanorods. Nano. Lett., 7, 3808—3812. 

The construction of "a calixarene with four peptide loops" serves two functions in this article. It serves as a simplified substitute for an antibody, though we doubt that the intent of the authors is the design of potential therapeutic agents. More important, the calixarene serves to test the theory of antibody function sketched in the preceding discussion Is this really the way that antibodies work The authors note that earlier attempts to mimic antibodies have been unsuccessful, and they propose the alternative strategy, which is the heart of the article The search for antibody mimics has not yet yielded compact and robust frameworks that reproduce the essential features of the CDRs. Our strategy is to use a macrocyclic scaffold to which multiple peptide loops in stable hairpin-turn conformations can be attached (p. 2681). 

Bouvet JP, Pires R, Iscaki S, Pillot J Nonimmune macromolecular complexes of Ig in human gut lumen. Probable enhancement of antibody functions. J Immunol 1993 151 2562-2572. 

Generally, polyclonal antibodies are easier to produce, and high-affinity polyclonal antibodies can be obtained. Monoclonal antibodies are more specific to a certain epitope. They provide continuous production of exactly the same defined reagent and are more preferable for excess-reagent assays. The double sandwich technique has used two antibodies from monoclonals or combinations of mono- and polyclonals, with specificity against two different epitopes of the analyte. One antibody functions as a capturing antibody for the analyte and the other as the label carrier (118). 

Campbell, G. A., Mutharasan, R. A method of measuring Escherichia coli 0157 H7 at 1 cell/mL in 1 liter sample using antibody functionalized piezoelectric-excited millimeter-sized cantilever sensor. Environmental Science and Technology 2007, 41 (5), 1668-1674... 

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