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Monoclonal antibodies receptor functions blocked

COLORECTAL ADENOCARCINOMA EGFR is a tyrosiue kinase receptor. Humanized monoclonal antibody chemotherapy to EGFR blocks its functional activation. Immuno-histochemical documentation of EGFR reactivity within colorectal cancers was once necessary to initiate anti-EGFR therapy. Currently, the initiation of therapy relies on documentation of a normal (wild-type) KRAS gene... [Pg.529]

Thus, molecular tools (antibodies and cDNA probes) to investigate auxin action are now available. We are now in the process of utilizing the polyclonal and monoclonal antibodies for immunopurification and also to probe receptor structure and function in maize and in other species. For example, preliminary results from Prof. J. Guern s laboratory (by H. Barbier-Brygoo, Gif) show that the antiserum blocks auxin-induced hyperpolarization of tobacco protoplasts. We are also seeking to use the antibodies to examine receptor features in auxin response mutants of several species and to explore signal transduction pathways. [Pg.112]

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See also in sourсe #XX -- [ Pg.341 ]



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Antibody functional

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Antibody receptor blocking

Blocking antibody

Function blocks

Functionalized receptor

Receptor functional

Receptor functions

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